ArticleArchives of oral biology2013
Genes expressed in dental enamel development are associated with molar-incisor hypomineralization.
Article in Archives of oral biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 213 citations in OpenAlex.
- Genetic Variants and Dental Caries Susceptibility: An Umbrella Review and Multilevel Meta-Analysis.Genes · 2026Pooled it
- An update of the aetiological factors involved in molar incisor hypomineralisation (MIH): a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Pooled it
- Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Association of LTF, ENAM, and AMELX polymorphisms with dental caries susceptibility: a meta-analysis.BMC oral health · 2020Pooled it
- Zirconia-reinforced glass ionomer restorations in molar incisor hypomineralization: a randomized controlled clinical trial.Clinical oral investigations · 2025Trial
- Effects of antibiotics on the developing enamel in neonatal mice.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2022Trial
- Trial
- Eighteen-month clinical performance of composite resin restorations with two different adhesive systems for molars affected by molar incisor hypomineralization.Clinical oral investigations · 2017Trial
- Effects of enamel matrix genes on dental caries are moderated by fluoride exposures.Human genetics · 2015Trial
- Integrative Analysis ofDentistry journal · 2026Article
- Integrated Management of Molar-Incisor Hypomineralisation in a Paediatric Patient: A Case-Based Perspective.Case reports in dentistry · 2026Article
- Effects of maternal morphine consumption on odontogenesis in rats: A histomorphometric study.Journal of dental research, dental clinics, dental prospects · 2025Article
- Frequencies of enamel hypomineralisation in permanent and primary molars in a medieval and early-modern-age population (7th - 17th c.) in Sains-en-Gohelle (Pas de Calais, France).Scientific reports · 2025Article
- Association between multiple genetic polymorphisms and molar-incisor hypomineralization: a population-based study.Journal of applied oral science : revista FOB · 2025Article
- Socioeconomic factors and feeding in the first two years of life associated with molar incisor hypomineralisation.Frontiers in dental medicine · 2025Article
- Effect of ibuprofen on amelogenesis in Wistar rats.Journal of applied oral science : revista FOB · 2025Article
- Current Knowledge of the Etiology and Management of Molar Incisor Hypomineralization in Children: A Narrative Review.Cureus · 2024Review
- Article
- Polymorphisms inThe Saudi dental journal · 2024Article
- AMELX gene association to early childhood caries in south-Indian children: a case-control study.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
Abstract
Genetic disturbances during dental development influence variation of number and shape of the dentition. In this study, we tested if genetic variation in enamel formation genes is associated with molar-incisor hypomineralization (MIH), also taking into consideration caries experience. DNA samples from 163 cases with MIH and 82 unaffected controls from Turkey, and 71 cases with MIH and 89 unaffected controls from Brazil were studied. Eleven markers in five genes [ameloblastin (AMBN), amelogenin (AMELX), enamelin (ENAM), tuftelin (TUFT1), and tuftelin-interacting protein 11 (TFIP11)] were genotyped by the TaqMan method. Chi-square was used to compare allele and genotype frequencies between cases with MIH and controls. In the Brazilian data, distinct caries experience within the MIH group was also tested for association with genetic variation in enamel formation genes. The ENAM rs3796704 marker was associated with MIH in both populations (Brazil: p=0.03; OR=0.28; 95% C.I.=0.06-1.0; Turkey: p=1.22e-012; OR=17.36; 95% C.I.=5.98-56.78). Associations between TFIP11 (p=0.02), ENAM (p=0.00001), and AMELX (p=0.01) could be seen with caries independent of having MIH or genomic DNA copies of Streptococcus mutans detected by real time PCR in the Brazilian sample. Several genes involved in enamel formation appear to contribute to MIH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.