ArticleChemistry & biology2013
Juxtaposition of chemical and mutation-induced developmental defects in zebrafish reveal a copper-chelating activity for kalihinol F.
Article in Chemistry & biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact.Trends in parasitology · 2026Review
- Current Understanding toward Isonitrile Group Biosynthesis and Mechanism.Chinese journal of chemistry · 2021Article
- Functional and genetic analyses of ZYG11B provide evidences for its involvement in OAVS.Molecular genetics & genomic medicine · 2020Article
- Development of a novel and rapid phenotype-based screening method to assess rice seedling growth.Plant methods · 2020Article
- How Surrogate and Chemical Genetics in Model Organisms Can Suggest Therapies for Human Genetic Diseases.Genetics · 2018Review
- Stereocontrolled Synthesis of Kalihinol C.Journal of the American Chemical Society · 2017Article
- Chemical screening in zebrafish for novel biological and therapeutic discovery.Methods in cell biology · 2017Review
- Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class.Journal of the American Chemical Society · 2016Article
- Synthesis and preliminary biological evaluation of a small library of hybrid compounds based on Ugi isocyanide multicomponent reactions with a marine natural product scaffold.Bioorganic & medicinal chemistry letters · 2015Article
- Zebrafish as tools for drug discovery.Nature reviews. Drug discovery · 2015Review
- Syntheses and biological studies of marine terpenoids derived from inorganic cyanide.Natural product reports · 2015Review
- 15 years of zebrafish chemical screening.Current opinion in chemical biology · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
A major hurdle in using complex systems for drug screening is the difficulty of defining the mechanistic targets of small molecules. The zebrafish provides an excellent model system for juxtaposing developmental phenotypes with mechanism discovery using organism genetics. We carried out a phenotype-based screen of uncharacterized small molecules in zebrafish that produced a variety of chemically induced phenotypes with potential genetic parallels. Specifically, kalihinol F caused an undulated notochord, defects in pigment formation, hematopoiesis, and neural development. These phenotypes were strikingly similar to the zebrafish mutant, calamity, an established model of copper deficiency. Further studies into the mechanism of action of kalihinol F revealed a copper-chelating activity. Our data support this mechanism of action for kalihinol F and the utility of zebrafish as an effective system for identifying therapeutic and target pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.