ArticleBritish journal of pharmacology1990
Effect of diadenosine polyphosphates on catecholamine secretion from isolated chromaffin cells.
Article in British journal of pharmacology, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 65 citations in OpenAlex.
- María Teresa Miras Portugal: a pioneer in the study of purinoceptors in chromaffin cells.Purinergic signalling · 2024Review
- Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.International journal of molecular sciences · 2019Article
- Purinergic signalling in endocrine organs.Purinergic signalling · 2014Review
- Selective stimulation of catecholamine release from bovine adrenal chromaffin cells by an ionotropic purinergic receptor sensitive to 2-methylthio ATP.BMC neuroscience · 2007Article
- Diadenosine polyphosphates evoke Ca2+ transients in guinea-pig brain via receptors distinct from those for ATP.The Journal of physiology · 1997Article
- Diadenosine polyphosphates induce intracellular Ca2+ mobilization in human neutrophils via a pertussis toxin sensitive G-protein.Immunology · 1997Article
- Selectivity and activity of adenine dinucleotides at recombinant P2X2 and P2Y1 purinoceptors.British journal of pharmacology · 1996Article
- Possible role of diadenosine polyphosphates as modulators of cardiac sensory-motor neurotransmission in guinea-pigs.The Journal of physiology · 1996Article
- Effects of PPADS and suramin on contractions and cytoplasmic Ca2+ changes evoked by AP4A, ATP and alpha, beta-methylene ATP in guinea-pig urinary bladder.British journal of pharmacology · 1996Article
- Cytosolic free Ca2+ oscillations induced by diadenosine 5',5"'-P1,P3-triphosphate and diadenosine 5',5"'-P1,P4-tetraphosphate in single rat hepatocytes are indistinguishable from those induced by ADP and ATP respectively.The Biochemical journal · 1995Article
- A reassessment of the modulatory role of cyclic AMP in catecholamine secretion by chromaffin cells.British journal of pharmacology · 1995Article
- Ap4A and ADP-beta-S binding to P2 purinoceptors present on rat brain synaptic terminals.British journal of pharmacology · 1993Article
- Ca(2+)-stores mobilization by diadenosine tetraphosphate, Ap4A, through a putative P2Y purinoceptor in adrenal chromaffin cells.British journal of pharmacology · 1992Article
- Functional comparisons of gastrin/cholecystokinin receptors in isolated preparations of gastric mucosa and ileum.British journal of pharmacology · 1992Article
- Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents.Proceedings of the National Academy of Sciences of the United States of America · 1992Article
- Characterization of diadenosine tetraphosphate (Ap4A) binding sites in cultured chromaffin cells: evidence for a P2y site.British journal of pharmacology · 1991Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The action of several diadenosine polyphosphates (AP3A, AP4A and AP5A) on basal, and on nicotine- and high K(+)-evoked, catecholamine (CA) release has been investigated. Each of the three diadenosine polyphosphates weakly but significantly increased basal CA secretion. This enhancement represented about 10% of the response evoked by 2 microM nicotine. 2. The evoked secretory response to diadenosine polyphosphates had an absolute requirement for extracellular Ca2+. 3. In contrast, these compounds had an inhibitory action on nicotine-evoked release. This response was concentration-dependent, EC50 values being 3.2 +/- 0.4 microM, 4.0 +/- 1.6 microM and 19.3 +/- 4.0 microM for AP3A, AP4A, and AP5A, respectively. The lower the concentration of nicotine used to evoke secretion, the higher the inhibitory power of these compounds. 4. The CA secretion evoked by K(+)-rich solutions was further enhanced by AP3A and AP5A, whereas AP4A inhibited it. The possible physiological role of these dual actions is discussed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.