ArticleBiophysical journal2013
Dual gating mechanism and function of P2X7 receptor channels.
Article in Biophysical journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Mechanisms underlying spontaneous and evoked calcium responses in oligodendrocyte precursor cells: A modeling investigation.PLoS computational biology · 2026Article
- Generalised Hodgkin-Huxley model captures human P2X and AMPA receptor currents.The Journal of physiology · 2026Article
- Article
- The Role of Extracellular Vesicles and Microparticles in Central Nervous System Disorders: Mechanisms, Biomarkers, and Therapeutic Potential.Cellular and molecular neurobiology · 2024Review
- The P2X7 Receptor in Autoimmunity.International journal of molecular sciences · 2023Review
- P2XInternational journal of molecular sciences · 2023Review
- Enlightening activation gating in P2X receptors.Purinergic signalling · 2022Review
- P2X7 Receptor-Related Genetic Mouse Models - Tools for Translational Research in Psychiatry.Frontiers in neural circuits · 2022Review
- Mathematical modelling of human P2X-mediated plasma membrane electrophysiology and calcium dynamics in microglia.PLoS computational biology · 2021Article
- Antagonism of the ATP-gated P2X7 receptor: a potential therapeutic strategy for cancer.Purinergic signalling · 2021Review
- Functional Coupling between the P2XInternational journal of molecular sciences · 2021Article
- High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts.PLoS computational biology · 2021Article
- Metabolic regulation of tissue-resident memory CD8Current opinion in pharmacology · 2021Review
- The P2X7 Receptor in Tumor Immunity.Frontiers in cell and developmental biology · 2021Article
- Role of Conserved Residues and F322 in the Extracellular Vestibule of the Rat P2X7 Receptor in Its Expression, Function and Dye Uptake Ability.International journal of molecular sciences · 2020Article
- P2X7 Receptor Activity Limits Accumulation of T Cells within Tumors.Cancer research · 2020Article
- Article
- P2X7 Purinergic Receptor Is Involved in the Pathophysiology of Mania: a Preclinical Study.Molecular neurobiology · 2020Article
- The P2X7 Receptor as Regulator of T Cell Development and Function.Frontiers in immunology · 2020Article
- P2X7 receptor restrains pathogenic Tfh cell generation in systemic lupus erythematosus.The Journal of experimental medicine · 2019Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The ATP-gated P2X7 receptor channel (P2X7R) operates as a cytolytic and apoptotic receptor but also controls sustained cellular responses, including cell growth and proliferation. However, it has not been clarified how the same receptor mediates such opposing effects. To address this question, we have combined electrophysiological, imaging, and mathematical studies using wild-type and mutant rat P2X7Rs. Activation of naïve (not previously stimulated) receptors by low agonist concentrations caused monophasic slow desensitizing currents and internalization of receptors without other changes in the cellular morphology, much like other P2XRs. In contrast, saturating agonist concentrations induced high-amplitude biphasic currents, reflecting pore dilation and causing rapid cell swelling and lysis. The existence of these two signaling patterns was accounted for using a revised Markov-state model that included, in addition to naïve and sensitized states, desensitized states. Occupancy of one or two ATP-binding sites of naïve receptors favored a slow transition to desensitized states, whereas occupancy of the third binding site favored a transition to sensitized/dilated states. Consistent with model predictions, nondilating P2X7R mutants always generated desensitizing currents. These results suggest that the level of saturation of the ligand binding sites determines the nature of the P2X7R gating and cellular actions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.