ArticleBiological psychiatry2014
Ventral striatum lesions enhance stimulus and response encoding in dorsal striatum.
Article in Biological psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Shared and distinct neural activity during anticipation and outcome of win and loss: A meta-analysis of the monetary incentive delay task.NeuroImage · 2022Pooled it
- Chronic ethanol exposure produces sex-dependent impairments in value computations in the striatum.Science advances · 2025Article
- Anterior cingulate cortex lesions impair multiple facets of task engagement not mediated by dorsomedial striatum neuron firing.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Aberrant prefrontal cortical-striatal functional connectivity in children with primary complex motor stereotypies.Cortex; a journal devoted to the study of the nervous system and behavior · 2021Article
- Prior Cocaine Exposure Increases Firing to Immediate Reward While Attenuating Cue and Context Signals Related to Reward Value in the Insula.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The Nucleus Accumbens Core Is Necessary for Responding to Incentive But Not Instructive Stimuli.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Previous cocaine self-administration disrupts reward expectancy encoding in ventral striatum.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Neural Activity in Ventral Medial Prefrontal Cortex Is Modulated More Before Approach Than Avoidance During Reinforced and Extinction Trial Blocks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- What Can Recordings in the Striatum Tell Us about Associative Learning?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Prior Cocaine Self-Administration Increases Response-Outcome Encoding That Is Divorced from Actions Selected in Dorsal Lateral Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Ventral striatal lesions disrupt dopamine neuron signaling of differences in cue value caused by changes in reward timing but not number.Behavioral neuroscience · 2016Article
- Article
- The Neural Representation of Goal-Directed Actions and Outcomes in the Ventral Striatum's Olfactory Tubercle.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Neurophysiology of Reward-Guided Behavior: Correlates Related to Predictions, Value, Motivation, Errors, Attention, and Action.Current topics in behavioral neurosciences · 2016Review
- Rule encoding in dorsal striatum impacts action selection.The European journal of neuroscience · 2015Article
- Orbitofrontal lesions eliminate signalling of biological significance in cue-responsive ventral striatal neurons.Nature communications · 2015Article
- Neural correlates of rules and conflict in medial prefrontal cortex during decision and feedback epochs.Frontiers in behavioral neuroscience · 2015Article
- From ventral-medial to dorsal-lateral striatum: neural correlates of reward-guided decision-making.Neurobiology of learning and memory · 2015Review
- Nucleus accumbens core lesions enhance two-way active avoidance.Neuroscience · 2014Article
- Impact of appetitive and aversive outcomes on brain responses: linking the animal and human literatures.Frontiers in systems neuroscience · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundThe development of addiction is thought to reflect a transition from goal-directed to stimulus-response driven behavior, functions attributed to ventral (VS) and dorsal striatum (DS), respectively. In line with this theory, neuroadaptations that occur during prolonged drug use progress from VS to DS. Here we ask if VS dysfunction alone, independent of drug use, can affect neural selectivity in DS.
methodsTo address this issue, we recorded from single neurons in DS while rats performed an odor-guided choice task for differently valued rewards in rats with and without unilateral VS lesions. In a separate group of animals, we used bilateral VS lesions to determine if VS was critical for performance on this task.
resultsWe describe data showing that unilateral lesions of VS enhance neural representations in DS during performance of a task that is dependent on VS. Furthermore, we show that VS is critical for reward-guided decision-making initially, but that rats regain function after several days.
conclusionsThese results suggest that loss of VS function, independent of chronic drug use, can trigger stronger encoding in DS in a reward-guided decision-making task and that the transition from VS to DS governed behavior observed in addiction might be due, in part, to initial loss of VS function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.