ArticleEvolutionary applications2013
An analysis of two island groups as potential sites for trials of transgenic mosquitoes for malaria control.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Integrating mosquito genomics into simulation modeling: opportunities for better-informed biocontrol.Current opinion in insect science · 2026Review
- A survey of indoor and outdoor Anopheles density, species composition and circumsporozoite rate of malaria vectors on the Bijagós Archipelago, Guinea-Bissau.Malaria journal · 2025Article
- Whole genome sequence analysis of population structure and insecticide resistance markers in Anopheles melas from the Bijagós Archipelago, Guinea-Bissau.Parasites & vectors · 2024Article
- A regional One Health approach to the risk of invasion by Anopheles stephensi in Mauritius.PLoS neglected tropical diseases · 2024Article
- Considerations for first field trials of low-threshold gene drive for malaria vector control.Malaria journal · 2024Review
- Genomic surveillance of Anopheles mosquitoes on the Bijagós Archipelago using custom targeted amplicon sequencing identifies mutations associated with insecticide resistance.Parasites & vectors · 2024Article
- Anopheles gambiae on remote islands in the Indian Ocean: origins and prospects for malaria elimination by genetic modification of extant populations.Scientific reports · 2023Article
- Population Genetics ofInsects · 2022Article
- The use of islands and cluster-randomized trials to investigate vector control interventions: a case study on the Bijagós archipelago, Guinea-Bissau.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Monitoring Needs for Gene Drive Mosquito Projects: Lessons From Vector Control Field Trials and Invasive Species.Frontiers in genetics · 2021Article
- Assessing connectivity despite high diversity in island populations of a malaria mosquito.Evolutionary applications · 2020Article
- A survey of Anopheles species composition and insecticide resistance on the island of Bubaque, Bijagos Archipelago, Guinea-Bissau.Malaria journal · 2020Article
- "Moving like birds": A qualitative study of population mobility and health implications in the Bijagós Islands, Guinea Bissau.Social science & medicine (1982) · 2019Article
- Origin and expansion of the mosquito Aedes aegypti in Madeira Island (Portugal).Scientific reports · 2019Article
- Transcontinental dispersal ofCommunications biology · 2019Article
- Reduced-representation sequencing identifies small effective population sizes of Anopheles gambiae in the north-western Lake Victoria basin, Uganda.Malaria journal · 2018Article
- Complete Anopheles funestus mitogenomes reveal an ancient history of mitochondrial lineages and their distribution in southern and central Africa.Scientific reports · 2018Article
- Spatio-temporal genetic structure of Anopheles gambiae in the Northwestern Lake Victoria Basin, Uganda: implications for genetic control trials in malaria endemic regions.Parasites & vectors · 2018Article
- Studies of Transgenic Mosquitoes in Disease-Endemic Countries: Preparation of Containment Facilities.Vector borne and zoonotic diseases (Larchmont, N.Y.) · 2018Article
- MALDI-TOF MS identification of Anopheles gambiae Giles blood meal crushed on Whatman filter papers.PloS one · 2017Article
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12 authors.
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Abstract
Considerable technological advances have been made towards the generation of genetically modified mosquitoes for vector control. In contrast, less progress has been made towards field evaluations of transformed mosquitoes which are critical for evaluating the success of, and hazards associated with, genetic modification. Oceanic islands have been highlighted as potentially the best locations for such trials. However, population genetic studies are necessary to verify isolation. Here, we used a panel of genetic markers to assess for evidence of genetic isolation of two oceanic island populations of the African malaria vector, Anopheles gambiae s.s. We found no evidence of isolation between the Bijagós archipelago and mainland Guinea-Bissau, despite separation by distances beyond the known dispersal capabilities of this taxon. Conversely, the Comoros Islands appear to be genetically isolated from the East African mainland, and thus represent a location worthy of further investigation for field trials. Based on assessments of gene flow within and between the Comoros islands, the island of Grande Comore was found to be genetically isolated from adjacent islands and also exhibited local population structure, indicating that it may be the most suitable site for trials with existing genetic modification technologies.
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