ArticleEvolutionary applications2013
Costs of crowding for the transmission of malaria parasites.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Impact of the intensity of infection in birds on Plasmodium development within Culex pipiens mosquitoes.Parasites & vectors · 2025Article
- Testing a non-destructive assay to track Plasmodium sporozoites in mosquitoes over time.Parasites & vectors · 2023Article
- Intervention reducing malaria parasite load in vector mosquitoes: No impact on Plasmodium falciparum extrinsic incubation period and the survival of Anopheles gambiae.PLoS pathogens · 2023Article
- Limited host availability disrupts the genetic correlation between virulence and transmission.Evolution letters · 2023Article
- Streamlining sporozoite isolation from mosquitoes by leveraging the dynamics of migration to the salivary glands.Malaria journal · 2022Article
- Epidemiology of a major honey bee pathogen, deformed wing virus: potential worldwide replacement of genotype A by genotype B.International journal for parasitology. Parasites and wildlife · 2022Article
- The circadian clock modulates Anopheles gambiae infection with Plasmodium falciparum.PloS one · 2022Article
- Field Relevant Variation in Ambient Temperature Modifies Density-Dependent Establishment ofFrontiers in microbiology · 2019Article
- Non-competitive resource exploitation within mosquito shapes within-host malaria infectivity and virulence.Nature communications · 2018Article
- Transmission traits of malaria parasites within the mosquito: Genetic variation, phenotypic plasticity, and consequences for control.Evolutionary applications · 2018Article
- Rethinking the extrinsic incubation period of malaria parasites.Parasites & vectors · 2018Review
- What is a vector?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Review
- Existing Infection Facilitates Establishment and Density of Malaria Parasites in Their Mosquito Vector.PLoS pathogens · 2015Article
- Interactions between a fungal entomopathogen and malaria parasites within a mosquito vector.Malaria journal · 2015Article
- Interspecific competition in honeybee intracellular gut parasites is asymmetric and favours the spread of an emerging infectious disease.Proceedings. Biological sciences · 2015Article
- What does not kill them makes them stronger: larval environment and infectious dose alter mosquito potential to transmit filarial worms.Proceedings. Biological sciences · 2014Article
- War and peace: social interactions in infections.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Review
- Temperature alters Plasmodium blocking by Wolbachia.Scientific reports · 2014Article
- Experimental Study on Plasmodium berghei, Anopheles Stephensi, and BALB/c Mouse System: Implications for Malaria Transmission Blocking Assays.Iranian journal of parasitologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The utility of using evolutionary and ecological frameworks to understand the dynamics of infectious diseases is gaining increasing recognition. However, integrating evolutionary ecology and infectious disease epidemiology is challenging because within-host dynamics can have counterintuitive consequences for between-host transmission, especially for vector-borne parasites. A major obstacle to linking within- and between-host processes is that the drivers of the relationships between the density, virulence, and fitness of parasites are poorly understood. By experimentally manipulating the intensity of rodent malaria (Plasmodium berghei) infections in Anopheles stephensi mosquitoes under different environmental conditions, we show that parasites experience substantial density-dependent fitness costs because crowding reduces both parasite proliferation and vector survival. We then use our data to predict how interactions between parasite density and vector environmental conditions shape within-vector processes and onward disease transmission. Our model predicts that density-dependent processes can have substantial and unexpected effects on the transmission potential of vector-borne disease, which should be considered in the development and evaluation of transmission-blocking interventions.
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