ArticleEvolutionary applications2013
The impact of natural selection on health and disease: uses of the population genetics approach in humans.
Article in Evolutionary applications, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Ancestral diversity in complex disease genetics: from discovery to translation.Nature reviews. Genetics · 2026Review
- A General Principle of Neuronal Evolution Reveals a Human-Accelerated Neuron Type Potentially Underlying the High Prevalence of Autism in Humans.Molecular biology and evolution · 2025Article
- A general principle of neuronal evolution reveals a human-accelerated neuron type potentially underlying the high prevalence of autism in humans.bioRxiv : the preprint server for biology · 2025Article
- Depression in adolescence and young adulthood: the difficulty to integrate motivational/emotional systems.Frontiers in psychology · 2024Review
- Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations.Molecular biology and evolution · 2023Article
- Genetics of Normotension Preventing Hypertension Leads to a Novel Physiological Paradigm.Reviews in cardiovascular medicine · 2022Review
- Adaptive Evolution in TRIF Leads to Discordance between Human and Mouse Innate Immune Signaling.Genome biology and evolution · 2021Article
- Detecting Genetic Ancestry and Adaptation in the Taiwanese Han People.Molecular biology and evolution · 2021Article
- The Genomic Architecture of Adaptation to Larval Malnutrition Points to a Trade-off with Adult Starvation Resistance in Drosophila.Molecular biology and evolution · 2021Article
- Biomimetics provides lessons from nature for contemporary ways to improve human health.Journal of clinical and translational science · 2021Review
- A planetary health perspective for kidney disease.Kidney international · 2020Article
- Comparative analysis of Plasmodium falciparum dihydrofolate-reductase gene sequences from different regions of India.Heliyon · 2020Article
- Antagonistic Pleiotropy in Human Disease.Journal of molecular evolution · 2020Review
- ImaGene: a convolutional neural network to quantify natural selection from genomic data.BMC bioinformatics · 2019Article
- Inflammaging: a new immune-metabolic viewpoint for age-related diseases.Nature reviews. Endocrinology · 2018Review
- Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention.Genes & nutrition · 2018Article
- Pancreatic cancer biology and genetics from an evolutionary perspective.Nature reviews. Cancer · 2016Review
- 267 Spanish Exomes Reveal Population-Specific Differences in Disease-Related Genetic Variation.Molecular biology and evolution · 2016Article
- The Impact of Evolutionary Driving Forces on Human Complex Diseases: A Population Genetics Approach.Scientifica · 2016Review
- Variation in NAT2 acetylation phenotypes is associated with differences in food-producing subsistence modes and ecoregions in Africa.BMC evolutionary biology · 2015Article
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2 authors.
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Abstract
Investigations of the legacy of natural selection in the human genome have proved particularly informative, pinpointing functionally important regions that have participated in our genetic adaptation to the environment. Furthermore, genetic dissection of the intensity and type of selection acting on human genes can be used to predict involvement in different forms and severities of human diseases. We review here the progress made in population genetics studies toward understanding the effects of selection, in its different forms and intensities, on human genome diversity. We discuss some outstanding, robust examples of genes and biological functions subject to strong dietary, climatic and pathogen selection pressures. We also explore the possible relationship between cancer and natural selection, a topic that has been largely neglected because cancer is generally seen as a late-onset disease. Finally, we discuss how the present-day incidence of some diseases of modern societies may represent a by-product of past adaptation to other selective forces and changes in lifestyle. This perspective thus illustrates the value of adopting a population genetics approach in delineating the biological mechanisms that have played a major evolutionary role in the way humans have genetically adapted to different environments and lifestyles over time.
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