ArticleJournal of pain research2013
Heart rate variability as a biomarker for autonomic nervous system response differences between children with chronic pain and healthy control children.
Article in Journal of pain research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery
A Pilot Study of Auricular Microstimulation to Determine if it Improves Vagal Modulation
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.
- Computational analysis of heart rate variability in ASD and ADHD: a systematic review.Frontiers in computational neuroscience · 2026Pooled it
- Emotion regulation and positive affect in the context of salivary alpha-amylase response to pain in children with cancer.Pediatric blood & cancer · 2018Trial
- Investigating associations between allostatic load phenotypes and clinical impairment in youth with chronic pain.Brain, behavior, & immunity - health · 2026Article
- Relationships Between Adiposity Measures and Heart Rate Variability in Children and Adolescents.Pediatric cardiology · 2026Article
- Article
- Heart rate variability (HRV) in juvenile fibromyalgia: a preliminary study.Pediatric rheumatology online journal · 2025Observational
- Development and Validation of a Multimodal Wearable Belt for Abdominal Biosignal Monitoring with Application to Irritable Bowel Syndrome.Micromachines · 2025Article
- Heart Rate Variability Applications in Medical Specialties: A Narrative Review.Applied psychophysiology and biofeedback · 2025Review
- Heart rate and heart rate variability during diagnostic and interventional neuroendovascular procedures.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025Article
- Relationship between heart rate variability and echocardiography indices of cardiac function in healthy individuals.Clinical physiology and functional imaging · 2025Article
- Article
- Physiological response to pain in patients with temporomandibular joint disorders during physiotherapy.Scientific reports · 2024Article
- Surgical treatment of refractory low back pain using implanted BurstDR spinal cord stimulation (SCS) in a cohort of patients without options for corrective surgery: Findings and results from the DISTINCT study, a prospective randomized multi-center-controlled trial.North American Spine Society journal · 2024Article
- Heart Rate Variability Applications in Strength and Conditioning: A Narrative Review.Journal of functional morphology and kinesiology · 2024Review
- Exploring a multimodal approach for utilizing digital biomarkers for childhood mental health screening.Frontiers in psychiatry · 2024Article
- Effects of COVID-19 on the Autonomic Cardiovascular System: Heart Rate Variability and Turbulence in Recovered Patients.Texas Heart Institute journal · 2023Article
- Objective wearable measures correlate with self-reported chronic pain levels in people with spinal cord stimulation systems.NPJ digital medicine · 2023Article
- Group Changes in Cortisol and Heart Rate Variability of Children with Down Syndrome and Children with Autism Spectrum Disorder during Dog-Assisted Therapy.Children (Basel, Switzerland) · 2023Article
- Interactive Cardio System for Healthcare Improvement.Sensors (Basel, Switzerland) · 2023Article
- Dynamic Phase Extraction: Applications in Pulse Rate Variability.Applied psychophysiology and biofeedback · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Studies in adults have demonstrated a relationship between lowered heart rate variability (HRV) and poor health. However, less is known about the role of autonomic arousal in children's well-being. The aim of the current study was to examine resting HRV in children with chronic pain compared to healthy control children and, further, to examine children's HRV following a series of acute experimental pain tasks in both groups. Participants included 104 healthy control children and 48 children with chronic pain aged 8-17 years. The laboratory session involved a 5-minute baseline electrocardiogram followed by four pain induction tasks: evoked pressure, cold pressor, focal pressure, and a conditioned pain modulation task. After the tasks were complete, a 5-minute post-task electrocardiogram recording was taken. Spectral analysis was used to capture high-frequency normalized power and the ratio of low-to-high frequency band power, signifying cardiac vagal tone and sympathetic balance, respectively. Results revealed that children with chronic pain had significantly lower resting HRV (signified by low high-frequency normalized power and high ratio of low-to-high frequency band power) compared to healthy children; moreover, a significant interaction between groups and time revealed that children with chronic pain displayed a static HRV response to the pain session compared to healthy children, whose HRV was reduced concomitant with the pain session. These findings suggest that children with chronic pain may have a sustained stress response with minimal variability in response to new acute pain stressors.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.