ArticleGenome research2013
Comparative analysis of mammalian Y chromosomes illuminates ancestral structure and lineage-specific evolution.
Article in Genome research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 160 citations in OpenAlex.
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- A chromosome-level genome assembly of the Leschenault's rousette (Rousettus leschenaultii).Scientific data · 2026Article
- A Dominant Founder Lineage Has Possible Fitness Costs for the Endangered Mexican Grey Wolf.Molecular ecology · 2026Article
- Signatures of the Anthropocene: Population Genomic Structure Detected in Pennsylvania Coyotes.Ecology and evolution · 2026Article
- Development of a Noninvasive Genotyping-In-Thousands (GTseq) Panel for Long-Term Conservation of Western Great Lakes Gray Wolves (Ecology and evolution · 2025Article
- Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest network.American journal of human genetics · 2025Article
- The value of hybrid genomes: Building two highly contiguous reference genome assemblies to advance Canis genomic studies.The Journal of heredity · 2024Article
- Large variance in inbreeding within the Iberian wolf population.The Journal of heredity · 2024Article
- Patterns of reproduction and autozygosity distinguish the breeding from nonbreeding gray wolves of Yellowstone National Park.The Journal of heredity · 2024Article
- Isogenic hiPSC models of Turner syndrome development reveal shared roles of inactive X and Y in the human cranial neural crest network.bioRxiv : the preprint server for biology · 2024Article
- Evolution and expression patterns of the neo-sex chromosomes of the crested ibis.Nature communications · 2024Article
- Endogenous feline leukemia virus long terminal repeat integration site diversity is highly variable in related and unrelated domestic cats.Retrovirology · 2024Article
- Trio-binning of a hinny refines the comparative organization of the horse and donkey X chromosomes and reveals novel species-specific features.Scientific reports · 2023Article
- Single-haplotype comparative genomics provides insights into lineage-specific structural variation during cat evolution.Nature genetics · 2023Article
- Genome sequencing of 2000 canids by the Dog10K consortium advances the understanding of demography, genome function and architecture.Genome biology · 2023Article
- Review
- Recovery of a marine keystone predator transforms terrestrial predator-prey dynamics.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Screening Y Chromosome Microdeletion in 1121 Men with Low Sperm Concentration and the Outcomes of Microdissection Testicular Sperm Extraction (mTESE) for Sperm Retrieval from Azoospermic Patients.The application of clinical genetics · 2023Article
- Article
- Unlocking Horse Y Chromosome Diversity.Genes · 2022Review
24 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although more than thirty mammalian genomes have been sequenced to draft quality, very few of these include the Y chromosome. This has limited our understanding of the evolutionary dynamics of gene persistence and loss, our ability to identify conserved regulatory elements, as well our knowledge of the extent to which different types of selection act to maintain genes within this unique genomic environment. Here, we present the first MSY (male-specific region of the Y chromosome) sequences from two carnivores, the domestic dog and cat. By combining these with other available MSY data, our multiordinal comparison allows for the first accounting of levels of selection constraining the evolution of eutherian Y chromosomes. Despite gene gain and loss across the phylogeny, we show the eutherian ancestor retained a core set of 17 MSY genes, most being constrained by negative selection for nearly 100 million years. The X-degenerate and ampliconic gene classes are partitioned into distinct chromosomal domains in most mammals, but were radically restructured on the human lineage. We identified multiple conserved noncoding elements that potentially regulate eutherian MSY genes. The acquisition of novel ampliconic gene families was accompanied by signatures of positive selection and has differentially impacted the degeneration and expansion of MSY gene repertoires in different species.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.