ArticleToxicological sciences : an official journal of the Society of Toxicology2013
A synergistic vascular effect of airborne particulate matter and nickel in a mouse model.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 50 citations in OpenAlex.
- Urinary Metal Levels after Repeated Edetate Disodium Infusions: Preliminary Findings.International journal of environmental research and public health · 2020Trial
- Angiotensin-Converting Enzyme (ACE) Inhibitors and Statins Mitigate Negative Cardiovascular and Pulmonary Effects of Particulate Matter in a Mouse Exposure Model.Antioxidants (Basel, Switzerland) · 2026Article
- Sex-specific modulation of T-type voltage-gated calcium channels in the renal artery of hypertensive rats.Frontiers in physiology · 2026Article
- Micro and nanoplastic inhalation during pregnancy elicits uterine endothelial dysfunction in Sprague Dawley rats by impeding nitric oxide signaling.bioRxiv : the preprint server for biology · 2025Article
- Noise, Air, and Heavy Metal Pollution as Risk Factors for Endothelial Dysfunction.European cardiology · 2023Review
- A comprehensive understanding of ambient particulate matter and its components on the adverse health effects based from epidemiological and laboratory evidence.Particle and fibre toxicology · 2022Review
- Physical Activity in Polluted Air-Net Benefit or Harm to Cardiovascular Health? A Comprehensive Review.Antioxidants (Basel, Switzerland) · 2021Review
- Concentrated Ambient PMEnvironmental health perspectives · 2018Article
- Combined effects of exposure to dim light at night and fine particulate matter on C3H/HeNHsd mice.Behavioural brain research · 2015Article
- Exposure to concentrated ambient particulate matter induces reversible increase of heart weight in spontaneously hypertensive rats.Particle and fibre toxicology · 2015Article
- The relationship between occupational metal exposure and arterial compliance.Journal of occupational and environmental medicine · 2015Observational
- Air pollution as a risk factor for type 2 diabetes.Toxicological sciences : an official journal of the Society of Toxicology · 2015Review
- In Vivo Exposures to Particulate Matter Collected from Saudi Arabia or Nickel Chloride Display Similar Dysregulation of Metabolic Syndrome Genes.Journal of toxicology and environmental health. Part A · 2015Article
- Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Both epidemiological and empirical studies have indicated that nickel (Ni) may play an important role in PM2.5 exposure-induced adverse cardiovascular effects. However, the underlying mechanism remains unclear. In the present study, we exposed mice to concentrated ambient PM2.5 (CAP), Ni, or coexposure to both CAP + Ni in a specially designed whole-body exposure system for a duration of 3 months and investigated their effects on vascular function, oxidative stress, and vascular inflammation. CAP + Ni exposure induced greater endothelial dysfunction compared with CAP or Ni alone. Ni exposure decreased endothelial nitric oxide synthase (eNOS) dimers in the aorta, which was potentiated by coexposure with CAP. CAP alone did not reduce NOS dimers but was more effective than Ni in decreasing phosphorylation of eNOS (S1177) and Akt (T308). Ni had minimal effects on the expression of vascular inflammatory genes but synergized with CAP in marked upregulation of tumor necrosis factor-alpha and monocyte chemotactic protein-1. The effects of Ni on NOS monomer formation in endothelial cells were redox dependent as evidenced by attenuation of effects by Tiron in cultured endothelial cells. Ni synergized with lipopolysaccharide, another bioactive component of CAP in reducing eNOS dimerization in cultured endothelial cells. Ni exposure induces endothelial dysfunction through oxidative stress-dependent inhibition of eNOS dimerization. Its interaction with other components of CAP may significantly contribute to the adverse cardiovascular effects of CAP exposure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.