Trial reportAJNR. American journal of neuroradiology2013
Role of semantic paradigms for optimization of language mapping in clinical FMRI studies.
Trial report in AJNR. American journal of neuroradiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A quantitative approach for measuring laterality in clinical fMRI for preoperative language mapping.Neuroradiology · 2021Pooled it
- American Society of Functional Neuroradiology-Recommended fMRI Paradigm Algorithms for Presurgical Language Assessment.AJNR. American journal of neuroradiology · 2017Guideline
- A Rapid fMRI Paradigm for Localisation of the Language Network.The European journal of neuroscience · 2026Article
- Noninvasive imaging techniques to map language areas using BOLD signal fluctuations in pediatric epilepsy: a review.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2026Review
- Assessing Language Lateralization through Gray Matter Volume: Implications for Preoperative Planning in Brain Tumor Surgery.Brain sciences · 2024Article
- Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Language Mapping in Brain Tumor Surgery: Validation With Direct Cortical Stimulation and Cortico-Cortical Evoked Potential.Korean journal of radiology · 2023Article
- Task-Based and Resting-State Functional MRI in Observing Eloquent Cerebral Areas Personalized for Epilepsy and Surgical Oncology Patients: A Review of the Current Evidence.Journal of personalized medicine · 2023Review
- Understanding Language Reorganization With Neuroimaging: How Language Adapts to Different Focal Lesions and Insights Into Clinical Applications.Frontiers in human neuroscience · 2022Review
- Alternative language paradigms for functional magnetic resonance imaging as presurgical tools for inducing crossed cerebro-cerebellar language activations in brain tumor patients.European radiology · 2022Article
- Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.Brain topography · 2021Article
- Monolingual and bilingual language networks in healthy subjects using functional MRI and graph theory.Scientific reports · 2021Article
- Resting State Functional MR Imaging of Language Function.Neuroimaging clinics of North America · 2021Review
- Tomographic Task-Related Functional Near-Infrared Spectroscopy in Acute Sport-Related Concussion: An Observational Case Study.International journal of molecular sciences · 2020Observational
- Clinical practice of language fMRI in epilepsy centers: a European survey and conclusions by the ESNR Epilepsy Working Group.Neuroradiology · 2020Article
- Sex Effect on Presurgical Language Mapping in Patients With a Brain Tumor.Frontiers in neuroscience · 2020Article
- fMRI-Targeted High-Angular Resolution Diffusion MR Tractography to Identify Functional Language Tracts in Healthy Controls and Glioma Patients.Frontiers in neuroscience · 2020Article
- Mapping of the Language Network With Deep Learning.Frontiers in neurology · 2020Article
- Resting-state functional magnetic resonance imaging versus task-based activity for language mapping and correlation with perioperative cortical mapping.Brain and behavior · 2019Article
- Functional MRI Task Comparison for Language Mapping in Neurosurgical Patients.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2019Article
- Repeatability of language fMRI lateralization and localization metrics in brain tumor patients.Human brain mapping · 2018Article
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3 authors.
Funding
Abstract
background and purposeThe optimal paradigm choice for language mapping in clinical fMRI studies is challenging due to the variability in activation among different paradigms, the contribution to activation of cognitive processes other than language, and the difficulties in monitoring patient performance. In this study, we compared language localization and lateralization between 2 commonly used clinical language paradigms and 3 newly designed dual-choice semantic paradigms to define a streamlined and adequate language-mapping protocol. MATERIALS AND
methodsTwelve healthy volunteers performed 5 language paradigms: Silent Word Generation, Sentence Completion, Visual Antonym Pair, Auditory Antonym Pair, and Noun-Verb Association. Group analysis was performed to assess statistically significant differences in fMRI percentage signal change and lateralization index among these paradigms in 5 ROIs: inferior frontal gyrus, superior frontal gyrus, middle frontal gyrus for expressive language activation, middle temporal gyrus, and superior temporal gyrus for receptive language activation.
resultsIn the expressive ROIs, Silent Word Generation was the most robust and best lateralizing paradigm (greater percentage signal change and lateralization index than semantic paradigms at P < .01 and P < .05 levels, respectively). In the receptive region of interest, Sentence Completion and Noun-Verb Association were the most robust activators (greater percentage signal change than other paradigms, P < .01). All except Auditory Antonym Pair were good lateralizing tasks (the lateralization index was significantly lower than other paradigms, P < .05).
conclusionsThe combination of Silent Word Generation and ≥1 visual semantic paradigm, such as Sentence Completion and Noun-Verb Association, is adequate to determine language localization and lateralization; Noun-Verb Association has the additional advantage of objective monitoring of patient performance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.