ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Direct and indirect lactate oxidation in trained and untrained men.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07426172 (Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.), which is not on this map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
Who cites it
31 citing papers in PubMed, 60 citations in OpenAlex.
- Exogenous lactate infusion (ELI) in traumatic brain injury: higher dose is better?Critical care (London, England) · 2025Trial
- Effects of exogenous lactate on lipid, protein, and glucose metabolism-a randomized crossover trial in healthy males.American journal of physiology. Endocrinology and metabolism · 2024Trial
- Trial
- Lactate recovery kinetics in response to high-intensity exercises.European journal of applied physiology · 2016Trial
- Trial
- The Effect of Septoplasty and Inferior Turbinate Reduction on Measures of Exercise Capacity.The Laryngoscope · 2026Article
- The value of blood lactate and lactate clearance rate in evaluating the prognosis of athletes with heat illness of varying degrees after high-intensity exercise.BMC sports science, medicine & rehabilitation · 2025Article
- The mitochondrial lactate oxidation complex: endpoint for carbohydrate carbon disposal.American journal of physiology. Endocrinology and metabolism · 2025Article
- Carbohydrate Restriction During Recovery from High-Intensity-Interval Training Enhances Fat Oxidation During Subsequent Exercise and Does Not Compromise Performance When Combined With Caffeine.Current developments in nutrition · 2025Article
- Delayed and diminished postprandial lactate shuttling in healthy older men and women.American journal of physiology. Endocrinology and metabolism · 2024Article
- Discriminative potential of exhaled breath condensate biomarkers with respect to chronic obstructive pulmonary disease.Journal of occupational medicine and toxicology (London, England) · 2024Article
- Cardiorespiratory fitness mediates cortisol and lactate responses to winter and summer marches.Journal of medical biochemistry · 2024Article
- Concepts of Lactate Metabolic Clearance Rate and Lactate Clamp for Metabolic Inquiry: A Mini-Review.Nutrients · 2023Review
- Black Ginger (Nutrients · 2022Article
- Tracing the lactate shuttle to the mitochondrial reticulum.Experimental & molecular medicine · 2022Review
- The role of lactate in sepsis and COVID-19: Perspective from contracting skeletal muscle metabolism.Experimental physiology · 2022Review
- Lower Muscle and Blood Lactate Accumulation in Sickle Cell Trait Carriers in Response to Short High-Intensity Exercise.Nutrients · 2022Article
- Chronic Lactate Exposure Decreases Mitochondrial Function by Inhibition of Fatty Acid Uptake and Cardiolipin Alterations in Neonatal Rat Cardiomyocytes.Frontiers in nutrition · 2022Article
- Regulation of Energy Substrate Metabolism in Endurance Exercise.International journal of environmental research and public health · 2021Review
- Delayed Rebound of Glycemia During Recovery Following Short-Duration High-Intensity Exercise: Are There Lactate and Glucose Metabolism Interactions?Frontiers in nutrition · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
Lactate has been shown to be an important oxidative fuel. We aimed to quantify the total lactate oxidation rate (Rox) and its direct vs. indirect (glucose that is gluconeogenically derived from lactate and subsequently oxidized) components (mg·kg(-1)·min(-1)) during rest and exercise in humans. We also investigated the effects of endurance training, exercise intensity, and blood lactate concentration ([lactate]b) on direct and indirect lactate oxidation. Six untrained (UT) and six trained (T) men completed 60 min of constant load exercise at power outputs corresponding to their lactate threshold (LT). T subjects completed two additional 60-min sessions of constant load exercise at 10% below the LT workload (LT-10%), one of which included a lactate clamp (LC; LT-10%+LC). Rox was higher at LT in T [22.7 ± 2.9, 75% peak oxygen consumption (Vo2peak)] compared with UT (13.4 ± 2.5, 68% Vo2peak, P < 0.05). Increasing [lactate]b (LT-10%+LC, 67% Vo2peak) significantly increased lactate Rox (27.9 ± 3.0) compared with its corresponding LT-10% control (15.9 ± 2.2, P < 0.05). Direct and indirect Rox increased significantly from rest to exercise, and their relative partitioning remained constant in all trials but differed between T and UT: direct oxidation comprised 75% of total lactate oxidation in UT and 90% in T, suggesting the presence of training-induced adaptations. Partitioning of total carbohydrate (CHO) use showed that subjects derived one-third of CHO energy from blood lactate, and exogenous lactate infusion increased lactate oxidation significantly, causing a glycogen-sparing effect in exercising muscle.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.