ArticlePediatric research2013
Postweaning exposure to a high-fat diet is associated with alterations to the hepatic histone code in Japanese macaques.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Initiation of metformin in early pregnancy results in fetal bioaccumulation, growth restriction, and renal dysmorphology in a primate model.American journal of obstetrics and gynecology · 2024Article
- Developmental Programming of the Fetal Immune System by Maternal Western-Style Diet: Mechanisms and Implications for Disease Pathways in the Offspring.International journal of molecular sciences · 2024Review
- Maternal diet alters long-term innate immune cell memory in fetal and juvenile hematopoietic stem and progenitor cells in nonhuman primate offspring.Cell reports · 2023Article
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- Western-style diet consumption impairs maternal insulin sensitivity and glucose metabolism during pregnancy in a Japanese macaque model.Scientific reports · 2021Article
- Developmental effects ofTrends in developmental biology · 2021Article
- Strength of nonhuman primate studies of developmental programming: review of sample sizes, challenges, and steps for future work.Journal of developmental origins of health and disease · 2020Review
- The development and ecology of the Japanese macaque gut microbiome from weaning to early adolescence in association with diet.American journal of primatology · 2019Article
- The Development of the Human Microbiome: Why Moms Matter.Gastroenterology clinics of North America · 2019Review
- Prenatal influences on temperament development: The role of environmental epigenetics.Development and psychopathology · 2018Review
- Modulations in the offspring gut microbiome are refractory to postnatal synbiotic supplementation among juvenile primates.BMC microbiology · 2018Article
- Conditional postnatal deletion of the neonatal murine hepatic circadian gene, Npas2, alters the gut microbiome following restricted feeding.American journal of obstetrics and gynecology · 2017Article
- Developmental origins of NAFLD: a womb with a clue.Nature reviews. Gastroenterology & hepatology · 2017Review
- Genomic Variants Associated with Resistance to High Fat Diet Induced Obesity in a Primate Model.Scientific reports · 2016Article
- Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function.Gut microbes · 2016Review
- Alterations in expression of imprinted genes from the H19/IGF2 loci in a multigenerational model of intrauterine growth restriction (IUGR).American journal of obstetrics and gynecology · 2016Article
- Obesity and Gestational Diabetes Mellitus Pathways for Programming in Mouse, Monkey, and Man—Where Do We Go Next? The 2014 Norbert Freinkel Award Lecture.Diabetes care · 2015Article
- Why primate models matter.American journal of primatology · 2014Review
- High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model.Nature communications · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundExpression of circadian gene, Npas2, is altered in fetal life with maternal high-fat (HF) diet exposure by virtue of alterations in the fetal histone code. We postulated that these disruptions would persist postnatally.
methodsPregnant macaques were fed a control (CTR) or HF diet and delivered at term. When offspring were weaned, they were placed on either CTR or HF diet for a period of 5 mo to yield four exposure models (in utero diet/postweaning diet: CTR/CTR n = 5; CTR/HF n = 4; HF/CTR n = 4; and HF/HF n = 5). Liver specimens were obtained at necropsy at 1 y of age.
resultsHepatic trimethylation of lysine 4 of histone H3 is decreased (CTR/HF 0.87-fold, P = 0.038; HF/CTR 0.84-fold, P = 0.038), whereas hepatic methyltransferase activity increased by virtue of diet exposure (HF/HF 1.3-fold, P = 0.019). Using chromatin immunoprecipitation to determine Npas2 promoter occupancy, we found alterations of both repressive and permissive histone modifications specifically with postweaning HF diet exposure.
conclusionWe found that altered Npas2 expression corresponds with a change in the histone code within the Npas2 promoter.
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Registered trials
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