ArticleCell death & disease2013
Exposure to bisphenol A disrupts meiotic progression during spermatogenesis in adult rats through estrogen-like activity.
Article in Cell death & disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.
- MicroRNAs as potential signatures of environmental exposure or effect: a systematic review.Environmental health perspectives · 2015Pooled it
- Response to comment on: protective effects of Panax ginseng against bisphenol A-induced testicular toxicity in rats.International journal of impotence research · 2026Article
- Environmental estrogens and animal reproductive health: mechanisms, biomarkers, and intervention approaches.Journal of animal science and biotechnology · 2026Review
- Transgenerational reproductive risks of BPA: epigenetic mechanisms and biomarker applications. A critical review.Environmental epigenetics · 2026Review
- Endocrine-disrupting chemicals in male reproductive health: exposure risks, reproductive toxicity and emerging perspectives.Frontiers in endocrinology · 2026Review
- 17α-Ethynylestradiol alters testicular epigenetic profiles and histone-to-protamine exchange in mice.Reproductive biology and endocrinology : RB&E · 2024Article
- Controversy on health-based guidance values for bisphenol A-the need of criteria for studies that serve as a basis for risk assessment.Archives of toxicology · 2024Article
- Melatonin alleviates oxidative stress damage in mouse testes induced by bisphenol A.Frontiers in cell and developmental biology · 2024Article
- Loss of Nuclear/DNA Integrity in Mouse Epididymal Spermatozoa after Short-Term Exposure to Low Doses of Dibutyl Phthalate or Bisphenol AF and Its Mitigation by Oral Antioxidant Supplementation.Antioxidants (Basel, Switzerland) · 2023Article
- Estrogenic and Non-Estrogenic Disruptor Effect of Zearalenone on Male Reproduction: A Review.International journal of molecular sciences · 2023Review
- Resveratrol ameliorates bisphenol A-induced testicular toxicity in adult male rats: a stereological and functional study.Basic and clinical andrology · 2023Article
- Bisphenol-A disturbs hormonal levels and testis mitochondrial activity, reducing male fertility.Human reproduction open · 2023Article
- Article
- Multi- and Transgenerational Effects of Environmental Toxicants on Mammalian Reproduction.Cells · 2022Review
- High-content imaging analyses of the effects of bisphenols and organophosphate esters on TM4 mouse Sertoli cells†.Biology of reproduction · 2022Article
- Retrieval action of zinc and folic acid for the restoration of normal reproductive function in bisphenol-A exposed male albino mice.Veterinarni medicina · 2022Article
- Article
- The Fate of Leydig Cells in Men with Spermatogenic Failure.Life (Basel, Switzerland) · 2022Review
- Acute Exposure to Bisphenol A Causes Oxidative Stress Induction with Mitochondrial Origin inJournal of fungi (Basel, Switzerland) · 2021Article
- In Vitro and Vivo Identification, Metabolism and Action of Xenoestrogens: An Overview.International journal of molecular sciences · 2021Review
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of bisphenol A (BPA) on the reproductive system is highly debated but has been associated with meiotic abnormalities. However, evidence is lacking with regard to the mechanisms involved. In order to explore the underlying mechanisms of BPA-induced meiotic abnormalities in adult male rats, we exposed 9-week-old male Wistar rats to BPA by gavage at 0, 2, 20 or 200 μg/kg body weight (bw)/day for 60 consecutive days. 17β-Estradiol (E2) was administered at 10 μg/kg bw/day as the estrogenic positive control. Treatments with 200 μg/kg bw/day of BPA and E2 significantly decreased sperm counts and inhibited spermiation, characterized by an increase in stage VII and decrease in stage VIII in the seminiferous epithelium. This was concomitant with a disruption in the progression of meiosis I and the persistence of meiotic DNA strand breaks in pachytene spermatocytes,and the ataxia-telangiectasia-mutated and checkpoint kinase 2 signal pathway was also activated; Eventually, germ cell apoptosis was triggered as evaluated by terminal dUTP nick-end labeling assay and western blot for caspase 3. Using the estrogen receptor (ER) antagonist ICI 182780, we determined that ER signaling mediated BPA-induced meiotic disruption and reproductive impairment. Our results suggest that ER signaling-mediated meiotic disruption may be a major contributor to the molecular events leading to BPA-related male reproductive disorders. These rodent data support the growing association between BPA exposure and the rapid increase in the incidence of male reproductive disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.