Observational studyCritical care (London, England)2013
The peripheral perfusion index and transcutaneous oxygen challenge test are predictive of mortality in septic patients after resuscitation.
Observational study in Critical care (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Meta-Analysis of the Prognostic Value of Skin Perfusion Parameters in Sepsis Patients: Evidence Integration Based on the Mottling Score, Capillary Refill Time, and Peripheral Perfusion Index.Shock (Augusta, Ga.) · 2026Pooled it
- [Association between peripheral perfusion, microcirculation and mortality in sepsis: a systematic review].Brazilian journal of anesthesiology (Elsevier)Pooled it
- Association between peripheral perfusion index and postoperative acute kidney injury in major noncardiac surgery patients receiving continuous vasopressors: a post hoc exploratory analysis of the VEGA-1 trial.British journal of anaesthesia · 2024Trial
- Trial
- Beyond macrocirculatory targets: a multimodal framework for microcirculatory and organ perfusion monitoring in sepsis.Critical care (London, England) · 2026Review
- Could Perfusion and Pleth Variability Index Be Useful in Managing Treatment and Morbidity in Patients with Gastrointestinal Bleeding?Journal of clinical medicine · 2026Article
- The reliability of the plethysmographic perfusion index for detecting fluid responsiveness in critically ill patients.Journal of intensive medicine · 2026Article
- Thermal intervention improves pulse oximetry accuracy in critically ill patients with low perfusion: a quasi-experimental study.Journal of intensive care · 2026Article
- Early detection of microcirculatory changes using simultaneous heated and unheated transcutaneous blood gas monitoring: a proof-of-concept study in a porcine lipopolysaccharide model of systemic inflammation.Frontiers in medicine · 2026Article
- The role of perfusion index in the evaluation of patients with cancer.BMC emergency medicine · 2025Article
- Article
- Article
- Peripheral perfusion index of pulse oximetry in adult patients: a narrative review.European journal of medical research · 2024Review
- Effect of Respiratory Failure on Peripheral and Organ Perfusion Markers in Severe COVID-19: A Prospective Cohort Study.Journal of clinical medicine · 2024Article
- "The peripheral perfusion index discriminates haemodynamic responses to induction of general anaesthesia".Journal of clinical monitoring and computing · 2023Article
- Association of the perfusion index with postoperative acute kidney injury: a retrospective study.Korean journal of anesthesiology · 2023Article
- Initial 24-h perfusion index of ICU admission is associated with acute kidney injury in perioperative critically ill patients: A retrospective cohort analysis.Journal of intensive medicine · 2023Article
- Feasibility of Precision Medicine in Hypertension Management-Scope and Technological Aspects.Journal of personalized medicine · 2022Article
- Transcutaneous oxygen pressure-related variables as noninvasive indicators of low lactate clearance in sepsis patients after resuscitation.Journal of clinical monitoring and computing · 2021Observational
- Post-ROSC peripheral perfusion index discriminates 30-day survival after out-of-hospital cardiac arrest.Internal and emergency medicine · 2021Observational
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe peripheral perfusion index (PI) is a noninvasive numerical value of peripheral perfusion, and the transcutaneous oxygen challenge test (OCT) is defined as the degree of transcutaneous partial pressure of oxygen (PtcO2) response to 1.0 FiO2. The value of noninvasive monitoring peripheral perfusion to predict outcome remains to be established in septic patients after resuscitation. Moreover, the prognostic value of PI has not been investigated in septic patients.
methodsForty-six septic patients, who were receiving PiCCO-Plus cardiac output monitoring, were included in the study group. Twenty stable postoperative patients were studied as a control group. All the patients inspired 1.0 of FiO2 for 10 minutes during the OCT. Global hemodynamic variables, traditional metabolic variables, PI and OCT related-variables were measured simultaneously at 24 hours after PiCCO catheter insertion. We obtained the 10 min-OCT ((PtcO2 after 10 minutes on inspired 1.0 oxygen)--(baseline PtcO2)), and the oxygen challenge index ((10 min-OCT)/(PaO2 on inspired 1.0 oxygen--baseline PaO2)) during the OCT.
resultsThe PI was significantly correlated with baseline PtcO2, 10 min-OCT and oxygen challenge index (OCI) in all the patients. The control group had a higher baseline PtcO2, 10 min-OCT and PI than the septic shock group. In the sepsis group, the macro hemodynamic parameters and ScvO2 showed no differences between survivors and nonsurvivors. The nonsurvivors had a significantly lower PI, 10 min-OCT and OCI, and higher arterial lactate level. The PI, 10 min-OCT and OCI predicted the ICU mortality with an accuracy that was similar to arterial lactate level. A PI<0.2 and a 10 min-OCT<66 mmHg were related to poor outcome after resuscitation.
conclusionsThe PI and OCT are predictive of mortality for septic patients after resuscitation. Further investigations are required to determine whether the correction of an impaired level of peripheral perfusion may improve the outcome of septic shock patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.