Evidence map›Paper›PMID 23787043›Full record

ArticleCurrent biology : CB2013

Scaffolding proteins: not such innocent bystanders.

F Donelson Smith, John D Scott

Abstract readComment
In one paragraph

Article in Current biology : CB, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. The focal adhesion protein talin is a mechanically gated A-kinase anchoring protein.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. ERK Signals: Scaffolding Scaffolds?Frontiers in cell and developmental biology · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

F Donelson SmithHoward Hughes Medical Institute, Department of Pharmacology, University of Washington, Seattle, WA 98195, USA. smithdon@uw.edu
John D Scott

Funding

MOLECULAR ANALYSIS OF PKA-ANCHORING PROTEIN INTERACTIONR01GM048231 · NIGMS · OREGON HEALTH AND SCIENCE UNIVERSITY · PI SCOTT, JOHN D · 1992 to 2003
$858k
NIGMS NIH HHS R01 GM048231
6 · The paper itself

Abstract

Sequential transfer of information from one enzyme to the next within the confines of a protein kinase scaffold enhances signal transduction. Though frequently considered to be inert organizational elements, two recent reports implicate kinase-scaffolding proteins as active participants in signal relay.

Indexed as

MitosisAnimalsAxin Proteinbeta CateninCell Cycle ProteinsDeoxyribonucleasesGTP-Binding ProteinsHumansLow Density Lipoprotein Receptor-Related Protein-6PhosphoproteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinstRNA MethyltransferasesWnt ProteinsAxin Proteinbeta CateninCell Cycle ProteinsDeoxyribonucleasesGTP-Binding ProteinsLow Density Lipoprotein Receptor-Related Protein-6PhosphoproteinsProtein Serine-Threonine KinasesSaccharomyces cerevisiae ProteinstRNA MethyltransferasesWnt Proteins

Identifiers

PMID23787043
PMCPMC3924780

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.