ArticleCell division2013
To divide or not to divide: revisiting liver regeneration.
Article in Cell division, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 167 citations in OpenAlex.
- Review
- Preoperative Beta-Hydroxy-Beta-Methyl-Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice.Acta physiologica (Oxford, England) · 2026Article
- Fatty liver regeneration after partial hepatectomy: an experimental study based on intravoxel incoherent motion and T2Magma (New York, N.Y.) · 2026Article
- Assessment of hepatic steatosis during rat liver regeneration after 70% partial hepatectomy using stereology and MRI-PDFF.Scientific reports · 2025Article
- Liver regeneration after partial hepatectomy: Triggers and mechanisms.World journal of hepatology · 2025Review
- Article
- Liver quad culture chip as a model for radiation injury research.Scientific reports · 2025Article
- Enhancement of adult liver regeneration in mice through the hepsin-mediated epidermal growth factor receptor signaling pathway.Communications biology · 2024Article
- HMGB2 Promotes De Novo Lipogenesis to Accelerate Hepatocyte Proliferation During Liver Regeneration.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024Article
- Phenotypic characterization of liver tissue heterogeneity through a next-generation 3D single-cell atlas.Scientific reports · 2024Article
- Future medicine: from molecular pathways to the collective intelligence of the body.Trends in molecular medicine · 2023Review
- Regenerative potential of multinucleated cells: bone marrow adiponectin-positive multinucleated cells take the lead.Stem cell research & therapy · 2023Article
- Liver cell therapies: cellular sources and grafting strategies.Frontiers of medicine · 2023Review
- Discussing the final size and shape of the reconstructed tissues in tissue engineering.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023Review
- Physics-based tissue simulator to model multicellular systems: A study of liver regeneration and hepatocellular carcinoma recurrence.PLoS computational biology · 2023Article
- Surgical Models of Liver Regeneration in Pigs: A Practical Review of the Literature for Researchers.Cells · 2023Review
- Assessment of Liver Regeneration in Patients Who Have Undergone Living Donor Hepatectomy for Living Donor Liver Transplantation.Vaccines · 2023Article
- Study of laser fluorescence spectroscopy in livers of rats with hypothermic ischemia.Acta cirurgica brasileira · 2023Article
- Intravital electrochemical nanosensor as a tool for the measurement of reactive oxygen/nitrogen species in liver diseases.Journal of nanobiotechnology · 2022Article
- The Influence of Interdisciplinary Work towards Advancing Knowledge on Human Liver Physiology.Cells · 2022Review
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration after partial hepatectomy has been studied extensively since the 19th century, establishing the long-standing model that hepatocytes, which account for most of the liver weight, proliferate to recover the original mass of the liver. The basis of this model is the fact that almost all hepatocytes undergo S phase, as shown by the incorporation of radioactive nucleotides during liver regeneration. However, DNA replication does not necessarily indicate the execution of cell division, and a possible change in hepatocyte size is not considered in the model. In addition, as 15-30% of hepatocytes in adult liver are binuclear, the difference in nuclear number may affect the mode of cell division during regeneration. Thus, the traditional model seems to be oversimplified. Recently, we developed new techniques to investigate the process of liver regeneration, and revealed interesting features of hepatocytes. In this review, we first provide a historical overview of how the widely accepted model of liver regeneration was established and then discuss some overlooked observations together with our recent findings. Finally, we describe the revised model and perspectives on liver regeneration research.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.