ArticleLipids in health and disease2013
Effect of Carissa opaca leaves extract on lipid peroxidation, antioxidant activity and reproductive hormones in male rats.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
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- Clinical Application of Bioextracts in Supporting the Reproductive System of Animals and Humans: Potential and Limitations.Evidence-based complementary and alternative medicine : eCAM · 2022Review
- Role of Antioxidant Natural Products in Management of Infertility: A Review of Their Medicinal Potential.Antioxidants (Basel, Switzerland) · 2020Review
- Effect of Acacia hydaspica R. Parker extract on lipid peroxidation, antioxidant status, liver function test and histopathology in doxorubicin treated rats.Lipids in health and disease · 2019Article
- Traditional knowledge on herbal drinks among indigenous communities in Azad Jammu and Kashmir, Pakistan.Journal of ethnobiology and ethnomedicine · 2018Article
- Evaluation of antioxidant, anti-inflammatory, analgesic and antipyretic activities of the stem bark of Sapindus mukorossi.BMC complementary and alternative medicine · 2017Article
- Evaluation of antioxidant profile of various solvent extracts of Carissa opaca leaves: an edible plant.Chemistry Central journal · 2017Article
- Protective effects of Carissa opaca fruits against CCl4-induced oxidative kidney lipid peroxidation and trauma in rat.Food & nutrition research · 2015Article
- Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice.The world journal of men's health · 2014Article
- Antidiabetic effect of Sida cordata in alloxan induced diabetic rats.BioMed research international · 2014Article
- Therapeutic Response ofDose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarissa opaca leaves are traditionally used in the treatment of male dysfunction and hormonal disorder as well as in oxidative stress in Pakistan and Asia. The present study was designed to assess the protective effects of methanolic extract of Carissa opaca leaves (MLC) on carbon tetrachloride (CCl4)-induced reproductive stress in male rats and bioactive constituents responsible for the activity.
methodsCCl4 was induced in 42 male rats for eight weeks and checked the protective efficacy of methanolic extract of Carissa opaca leaves at various hormonal imbalances, alteration of antioxidant enzymes, DNA fragmentation levels and lipid peroxidation caused testicular fibrosis in testis while High performance Liquid Chromatography (HPLC) was used for detection of bioactive components.
resultsHPLC characterization revealed the presence of isoquercitin, hyperoside, vitexin, myricetin and kaempherol. CCl4 caused significant alteration in the secretion of reproductive hormones. Activity of antioxidant enzymes viz; catalase, superoxide dimutase and phase II metabolizing enzymes including glutathione peroxidase, glutathione reductase and reduced glutathione was decreased while DNA fragmentation, hydrogen per oxide contents and thiobarbituric acid reactive substances (TBARS) were increased with CCl4 treatment. Co-administration of 100 mg/kg and 200 mg/kg b.w. MLC effectively ameliorated the alterations in the biochemical markers; hormonal and molecular levels.
conclusionProtective effects of methanolic extract of Carissa opaca against CCl4-induced antioxidant and hormonal dysfunction which might be due to bioactive compound present in extract.
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