ArticleGenes, brain, and behavior2013
The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine.
Article in Genes, brain, and behavior, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 41 citations in OpenAlex.
- Understanding food addiction in obesity: a genetic perspective.Journal of eating disorders · 2025Article
- Motivational dysregulation with melanocortin 4 receptor haploinsufficiency.NeuroImmune pharmacology and therapeutics · 2024Article
- Control of goal-directed and inflexible actions by dorsal striatal melanocortin systems, in coordination with the central nucleus of the amygdala.Progress in neurobiology · 2024Article
- Chronic Nicotine Consumption and Withdrawal Regulate Melanocortin Receptor, CRF, and CRF Receptor mRNA Levels in the Rat Brain.Brain sciences · 2024Article
- Melanocortin-4 receptor in macrophages attenuated angiotensin II-induced abdominal aortic aneurysm in mice.Scientific reports · 2023Article
- Actions of feeding-related peptides on the mesolimbic dopamine system in regulation of natural and drug rewards.Addiction neuroscience · 2022Article
- The atypical antipsychotic risperidone targets hypothalamic melanocortin 4 receptors to cause weight gain.The Journal of experimental medicine · 2021Article
- Article
- The melanocortin system as a potential target for treating alcohol use disorders: A review of pre-clinical data.Brain research · 2020Review
- Behavioral Alterations in Mice Carrying HomozygousFrontiers in neuroscience · 2020Article
- Motivational valence is determined by striatal melanocortin 4 receptors.The Journal of clinical investigation · 2018Article
- Hunger and Satiety Gauge Reward Sensitivity.Frontiers in endocrinology · 2017Review
- The Role of the Melanocortin System in Metabolic Disease: New Developments and Advances.Neuroendocrinology · 2017Review
- Loss of estrogen-related receptor alpha disrupts ventral-striatal synaptic function in female mice.Neuroscience · 2016Article
- Melanocortin-4 receptor-regulated energy homeostasis.Nature neuroscience · 2016Review
- Moderate voluntary exercise attenuates the metabolic syndrome in melanocortin-4 receptor-deficient rats showing central dopaminergic dysregulation.Molecular metabolism · 2015Article
- Cognitive and autonomic determinants of energy homeostasis in obesity.Nature reviews. Endocrinology · 2015Review
- Regulation of glucose tolerance and sympathetic activity by MC4R signaling in the lateral hypothalamus.Diabetes · 2015Article
- Cocaine decreases saccharin preference without altering sweet taste sensitivity.Pharmacology, biochemistry, and behavior · 2015Article
- MC4R expression in pedunculopontine nucleus involved in the modulation of midbrain dopamine system.International journal of clinical and experimental pathology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
While it is known that mice lacking melanocortin 4 receptor (MC4R) expression develop hyperphagia resulting in early-onset obesity, the specific neural circuits that mediate this process remain unclear. Here, we report that selective restoration of MC4R expression within dopamine-1 receptor-expressing neurons [MC4R/dopamine 1 receptor (D1R) mice] partially blunts the severe obesity seen in MC4R-null mice by decreasing meal size, but not meal frequency, in the dark cycle. We also report that both acute cocaine-induced anorexia and the development of locomotor sensitization to repeated administration of cocaine are blunted in MC4R-null mice and normalized in MC4R/D1R mice. Neuronal retrograde tracing identifies the lateral hypothalamic area as the primary target of MC4R-expressing neurons in the nucleus accumbens. Biochemical studies in the ventral striatum show that phosphorylation of DARPP-32(Thr) (-34) and GluR1(Ser) (-845) is diminished in MC4R-null mice after chronic cocaine administration but rescued in MC4R/D1R mice. These findings highlight a physiological role of MC4R-mediated signaling within D1R neurons in the long-term regulation of energy balance and behavioral responses to cocaine.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.