ArticlePLoS neglected tropical diseases2013
Impact of three rounds of mass drug administration on lymphatic filariasis in areas previously treated for onchocerciasis in Sierra Leone.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Compliance with anthelmintic treatment in the neglected tropical diseases control programmes: a systematic review.Parasites & vectors · 2016Pooled it
- Assessing the need to implement mass drug administration against Wuchereria bancrofti infection using both human serology and xenomonitoring in the urban conurbation of Monrovia, Liberia.PLoS neglected tropical diseases · 2025Article
- Side Effects following School Deworming among School-Age Children in Oti Region, Ghana.Journal of tropical medicine · 2024Article
- Factors determining preventive chemotherapy uptake against soil-transmitted helminthiasis among school-age children in Ghana.Parasitology research · 2022Article
- [School-age children'S knowledge and perceptions concerning Soil-transmitted Helminthiases and Targeted Preventive Chemotherapy in Ghana's Oti Region].Medecine tropicale et sante internationale · 2022Article
- Progress on elimination of lymphatic filariasis in Sierra Leone.Parasites & vectors · 2018Article
- Significant decline in lymphatic filariasis associated with nationwide scale-up of insecticide-treated nets in Zambia.Parasite epidemiology and control · 2017Article
- Continental-scale, data-driven predictive assessment of eliminating the vector-borne disease, lymphatic filariasis, in sub-Saharan Africa by 2020.BMC medicine · 2017Article
- First evidence of lymphatic filariasis transmission interruption in Cameroon: Progress towards elimination.PLoS neglected tropical diseases · 2017Article
- Mathematical modelling of lymphatic filariasis elimination programmes in India: required duration of mass drug administration and post-treatment level of infection indicators.Parasites & vectors · 2016Article
- The impact of residual infections on Anopheles-transmitted Wuchereria bancrofti after multiple rounds of mass drug administration.Parasites & vectors · 2015Article
- Elimination of lymphatic filariasis in the Gambia.PLoS neglected tropical diseases · 2015Article
- Lymphatic filariasis control in Tanga Region, Tanzania: status after eight rounds of mass drug administration.Parasites & vectors · 2014Article
- The effect of a health communication campaign on compliance with mass drug administration for schistosomiasis control in western Kenya--the SCORE project.The American journal of tropical medicine and hygiene · 2014Article
- No evidence for lymphatic filariasis transmission in big cities affected by conflict related rural-urban migration in Sierra Leone and Liberia.PLoS neglected tropical diseases · 2014Article
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Authors and funding
7 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background1974-2005 studies across Sierra Leone showed onchocerciasis endemicity in 12 of 14 health districts (HDs) and baseline studies 2005-2008 showed lymphatic filariasis (LF) endemicity in all 14 HDs. Three integrated annual mass drug administration (MDA) were conducted in the 12 co-endemic districts 2008-2010 with good geographic, programme and drug coverage. Midterm assessment was conducted 2011 to determine impact of these MDAs on LF in these districts. METHODOLOGY/PRINCIPAL
findingsThe mf prevalence and intensity in the 12 districts were determined using the thick blood film method and results compared with baseline data from 2007-2008. Overall mf prevalence fell from 2.6% (95% CI: 2.3%-3.0%) to 0.3% (95% CI: 0.19%-0.47%), a decrease of 88.5% (p = 0.000); prevalence was 0.0% (100.0% decrease) in four districts: Bo, Moyamba, Kenema and Kono (p = 0.001, 0.025, 0.085 and 0.000 respectively); and seven districts had reductions in mf prevalence of between 70.0% and 95.0% (p = 0.000, 0.060, 0.001, 0.014, 0.000, 0.000 and 0.002 for Bombali, Bonthe, Kailahun, Kambia, Koinadugu, Port Loko and Tonkolili districts respectively). Pujehun had baseline mf prevalence of 0.0%, which was maintained. Only Bombali still had an mf prevalence ≥1.0% (1.58%, 95% CI: 0.80%-3.09%)), and this is the district that had the highest baseline mf prevalence: 6.9% (95% CI: 5.3%-8.8%). Overall arithmetic mean mf density after three MDAs was 17.59 mf/ml (95% CI: 15.64 mf/ml-19.55 mf/ml) among mf positive individuals (65.4% decrease from baseline of 50.9 mf/ml (95% CI: 40.25 mf/ml-61.62 mf/ml; p = 0.001) and 0.05 mf/ml (95% CI: 0.03 mf/ml-0.08 mf/ml) for the entire population examined (96.2% decrease from baseline of 1.32 mf/ml (95% CI: 1.00 mf/ml-1.65 mf/ml; p = 0.000)). CONCLUSIONS/SIGNIFICANCE: The results show that mf prevalence decreased to <1.0% in all but one of the 12 districts after three MDAs. Overall mf density reduced by 65.0% among mf-positive individuals, and 95.8% for the entire population.
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