ArticlePLoS neglected tropical diseases2013
Genetic structure and evolution of the Leishmania genus in Africa and Eurasia: what does MLSA tell us.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed.
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- Self-application of aminoglycoside-based creams to treat cutaneous leishmaniasis in travelers.PLoS neglected tropical diseases · 2023Article
- Genetic Diversity and Population Structure ofPathogens (Basel, Switzerland) · 2023Article
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- Surveillance of leishmaniasis cases from 15 European centres, 2014 to 2019: a retrospective analysis.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
- Dipeptidyl peptidase III as a DNA marker to investigate epidemiology and taxonomy of Old World Leishmania species.PLoS neglected tropical diseases · 2021Article
- Updates on Geographical Dispersion ofPathogens (Basel, Switzerland) · 2021Article
- Untapped potential: The utility of drylands for testing eco-evolutionary relationships between hosts and parasites.International journal for parasitology. Parasites and wildlife · 2020Article
- Identification of divergent Leishmania (Viannia) braziliensis ecotypes derived from a geographically restricted area through whole genome analysis.PLoS neglected tropical diseases · 2019Article
- Exploiting genetic polymorphisms in metabolic enzymes for rapid screening of Leishmania infantum genotypes.Parasites & vectors · 2018Article
- Genetic polymorphism in Leishmania infantum isolates from human and animals determined by nagt PCR-RFLP.Infectious diseases of poverty · 2018Article
- Cyclospora cayetanensis infections among diarrheal outpatients in Shanghai: a retrospective case study.Frontiers of medicine · 2018Article
- Cutaneous leishmaniasis in northwestern Saudi Arabia: identification of sand fly fauna and parasites.Parasites & vectors · 2017Article
- Identification of Leishmania by Matrix-Assisted Laser Desorption Ionization-Time of Flight (MALDI-TOF) Mass Spectrometry Using a Free Web-Based Application and a Dedicated Mass-Spectral Library.Journal of clinical microbiology · 2017Article
- Phlebotomine sand fly-borne pathogens in the Mediterranean Basin: Human leishmaniasis and phlebovirus infections.PLoS neglected tropical diseases · 2017Review
- The genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania.Scientific reports · 2017Article
- Comparison of Leishmania typing results obtained from 16 European clinical laboratories in 2014.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2016Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Leishmaniasis is a complex parasitic disease from a taxonomic, clinical and epidemiological point of view. The role of genetic exchanges has been questioned for over twenty years and their recent experimental demonstration along with the identification of interspecific hybrids in natura has revived this debate. After arguing that genetic exchanges were exceptional and did not contribute to Leishmania evolution, it is currently proposed that interspecific exchanges could be a major driving force for rapid adaptation to new reservoirs and vectors, expansion into new parasitic cycles and adaptation to new life conditions. To assess the existence of gene flows between species during evolution we used MLSA-based (MultiLocus Sequence Analysis) approach to analyze 222 Leishmania strains from Africa and Eurasia to accurately represent the genetic diversity of this genus. We observed a remarkable congruence of the phylogenetic signal and identified seven genetic clusters that include mainly independent lineages which are accumulating divergences without any sign of recent interspecific recombination. From a taxonomic point of view, the strong genetic structuration of the different species does not question the current classification, except for species that cause visceral forms of leishmaniasis (L. donovani, L. infantum and L. archibaldi). Although these taxa cause specific clinical forms of the disease and are maintained through different parasitic cycles, they are not clearly distinct and form a continuum, in line with the concept of species complex already suggested for this group thirty years ago. These results should have practical consequences concerning the molecular identification of parasites and the subsequent therapeutic management of the disease.
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