ArticlePloS one2013
Modelling the effect of a functional endothelium on the development of in-stent restenosis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 63 citations in OpenAlex.
- Impact of Tissue Damage and Hemodynamics on Restenosis Following Percutaneous Transluminal Angioplasty: A Patient-Specific Multiscale Model.Annals of biomedical engineering · 2024Article
- Haemodynamics of stent-mounted neural interfaces in tapered and deformed blood vessels.Scientific reports · 2024Article
- Chitosan-salvianolic acid B coating on the surface of nickel-titanium alloy inhibits proliferation of smooth muscle cells and promote endothelialization.Frontiers in bioengineering and biotechnology · 2023Article
- A predictive multiscale model of in-stent restenosis in femoral arteries: linking haemodynamics and gene expression with an agent-based model of cellular dynamics.Journal of the Royal Society, Interface · 2022Article
- Uncertainty quantification of a three-dimensional in-stent restenosis model with surrogate modelling.Journal of the Royal Society, Interface · 2022Article
- A homogenized constrained mixture model of restenosis and vascular remodelling after balloon angioplasty.Journal of the Royal Society, Interface · 2021Article
- Multiscale Computational Modeling of Vascular Adaptation: A Systems Biology Approach Using Agent-Based Models.Frontiers in bioengineering and biotechnology · 2021Review
- The Combined Contribution of Vascular Endothelial Cell Migration and Adhesion to Stent Re-endothelialization.Frontiers in cell and developmental biology · 2021Article
- Mechanistic evaluation of long-term in-stent restenosis based on models of tissue damage and growth.Biomechanics and modeling in mechanobiology · 2020Article
- Location-Specific Comparison Between a 3D In-Stent Restenosis Model and Micro-CT and Histology Data from Porcine In Vivo Experiments.Cardiovascular engineering and technology · 2019Article
- Semi-intrusive multiscale metamodelling uncertainty quantification with application to a model of in-stent restenosis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2019Article
- A versatile hybrid agent-based, particle and partial differential equations method to analyze vascular adaptation.Biomechanics and modeling in mechanobiology · 2019Article
- Uncertainty Quantification of a Multiscale Model for In-Stent Restenosis.Cardiovascular engineering and technology · 2018Article
- Optimizing endothelial cell functionalization for cell therapy of vascular proliferative disease using a direct contact co-culture system.Drug delivery and translational research · 2018Article
- Nanomatrix Coated Stent Enhances Endothelialization but Reduces Platelet, Smooth Muscle Cell, and Monocyte Adhesion under Physiologic Conditions.ACS biomaterials science & engineering · 2018Article
- A cell-based mechanical model of coronary artery tunica media.Journal of the Royal Society, Interface · 2017Article
- RNA-Eluting Surfaces for the Modulation of Gene Expression as A Novel Stent Concept.Pharmaceuticals (Basel, Switzerland) · 2017Article
- A Comparison of Fully-Coupled 3D In-Stent Restenosis Simulations toFrontiers in physiology · 2017Article
- Towards the virtual artery: a multiscale model for vascular physiology at the physics-chemistry-biology interface.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016Article
- Magnetically enhanced cell delivery for accelerating recovery of the endothelium in injured arteries.Journal of controlled release : official journal of the Controlled Release Society · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Treatment of stenosed coronary arteries by balloon angioplasty and stenting results in arterial injury including severe damage to the endothelium at the site of treatment and initiates a complex cascade of inflammatory processes that may lead to the development of in-stent restenosis (ISR). Many clinical and biological factors involved in the progression of restenotic lesions have been studied in detail over the past few years but the mystery behind the pathophysiological mechanisms of this disease is still unresolved. In the present work, the effects of re-endothelialization and nitric oxide release on neointimal growth are investigated in-silico using a two dimensional multi-scale model of ISR. The effect of stent deployment depths on the development of ISR is studied as a function of time after stenting. Two dimensional domains were prepared by deploying bare metal stent struts at three different deployment depths into the tissue. Shear stress distribution on endothelial cells, obtained by blood flow simulations, was translated into nitric oxide production that keeps the smooth muscle cells in quiescent state. The cellular growth trends were plotted as a function of time and the data indicate a positive correlation between the neointimal growths and strut deployment depths in the presence of a functional endothelium, in qualitative agreement with in-vivo data. Additionally, no ISR is observed if a functional endothelium appears much earlier.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.