ArticlePloS one2013
The pyloric caeca area is a major site for IgM(+) and IgT(+) B cell recruitment in response to oral vaccination in rainbow trout.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 93 citations in OpenAlex.
- Stressor- and Tissue-Specific Regulation of the Corticotropin-Releasing Factor System Across Epithelial Tissues in Rainbow Trout.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- Dissection of the global responses of mandarin fish pyloric cecum to an acute ranavirus (MRV) infection reveals the formation of serositis and then ascites.Journal of virology · 2025Article
- IgT and IgD dominance in the teleost central nervous system.Frontiers in immunology · 2025Article
- Protective IgM-mediated immunity againstFrontiers in immunology · 2025Article
- Better the devil you know: sympatric fish host copes better than allopatric with a myxozoan parasite.Frontiers in cellular and infection microbiology · 2025Article
- Distinct distribution and responses of IgMFrontiers in immunology · 2024Article
- An Introduction to Relevant Immunology Principles with Respect to Oral Vaccines in Aquaculture.Microorganisms · 2023Review
- Article
- The Distribution of IgT mRNAAnimals : an open access journal from MDPI · 2023Article
- Nanovaccines to CombatVaccines · 2023Review
- The Alimentary Tract of African Bony-Tongue,Animals : an open access journal from MDPI · 2022Article
- Article
- Current status and development prospects of aquatic vaccines.Frontiers in immunology · 2022Review
- Functional and Phenotypic Characterization of B Cells in the Teleost Adipose Tissue.Frontiers in immunology · 2022Article
- Oral Administration ofViruses · 2021Article
- Protection of Teleost Fish against Infectious Diseases through Oral Administration of Vaccines: Update 2021.International journal of molecular sciences · 2021Review
- Dietary Administration of Novel Multistrain Probiotics from Healthy Grouper Intestines Promotes the Intestinal Immune Response against NNV Infection.Life (Basel, Switzerland) · 2021Article
- Mucosal immunoglobulins of teleost fish: A decade of advances.Developmental and comparative immunology · 2021Review
- Gut Immune System and the Implications of Oral-Administered Immunoprophylaxis in Finfish Aquaculture.Frontiers in immunology · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although previous studies have characterized some aspects of the immune response of the teleost gut in response to diverse pathogens or stimuli, most studies have focused on the posterior segments exclusively. However, there are still many details of how teleost intestinal immunity is regulated that remain unsolved, including the location of IgM(+) and IgT(+) B cells along the digestive tract and their role during the course of a local stimulus. Thus, in the current work, we have studied the B cell response in five different segments of the rainbow trout (Oncorhynchus mykiss) digestive tract in both naïve fish and fish orally vaccinated with an alginate-encapsulated DNA vaccine against infectious pancreatic necrosis virus (IPNV). IgM(+) and IgT(+) cells were identified all along the tract with the exception of the stomach in naïve fish. While IgM(+) cells were mostly located in the lamina propria (LP), IgT(+) cells were primarily localized as intraepithelial lymphocytes (IELs). Scattered IgM(+) IELs were only detected in the pyloric caeca. In response to oral vaccination, the pyloric caeca region was the area of the digestive tract in which a major recruitment of B cells was demonstrated through both real time PCR and immunohistochemistry, observing a significant increase in the number of both IgM(+) and IgT(+) IELs. Our findings demonstrate that both IgM(+) and IgT(+) respond to oral stimulation and challenge the paradigm that teleost IELs are exclusively T cells. Unexpectedly, we have also detected B cells in the fat tissue associated to the digestive tract that respond to vaccination, suggesting that these cells surrounded by adipocytes also play a role in mucosal defense.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.