ArticlePloS one2013
Crucial role for CD69 in the pathogenesis of dextran sulphate sodium-induced colitis.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Retinoic Acid Modulates Immune Differentiation in a Human Small Intestinal In Vitro Model.Cells · 2025Article
- T cells in cardiac health and disease.The Journal of clinical investigation · 2025Review
- Unraveling CD69 signaling pathways, ligands and laterally associated molecules.EXCLI journal · 2023Review
- Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease.Discovery immunology · 2023Review
- Effect of cigarette smoke extract on the intestinal microenvironment of ulcerative colitis tissue.JGH open : an open access journal of gastroenterology and hepatology · 2020Article
- Myosin Light Chain 9/12 Regulates the Pathogenesis of Inflammatory Bowel Disease.Frontiers in immunology · 2020Article
- A new therapeutic target: the CD69-Myl9 system in immune responses.Seminars in immunopathology · 2019Review
- Synbiotics suppress colitis-induced tumorigenesis in a colon-specific cancer mouse model.PloS one · 2019Article
- Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells.Frontiers in immunology · 2018Review
- CD69: from activation marker to metabolic gatekeeper.European journal of immunology · 2017Review
- CD69 is the crucial regulator of intestinal inflammation: a new target molecule for IBD treatment?Journal of immunology research · 2015Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
CD69 is a membrane molecule transiently expressed on activated lymphocytes, and its selective expression in inflammatory infiltrates suggests that it plays a role in the pathogenesis of inflammatory diseases. In this study, we used CD69-deficient (CD69 KO) mice to assess the role of CD69 in the pathogenesis of dextran sulphate sodium (DSS)-induced acute and chronic colitis. The severity of colitis was assessed by the survival rate, clinical signs, colon length, histological examination and the expression of cytokines and chemokines in the large intestines. Both acute and chronic colitis were attenuated in the CD69 KO mice, as reflected by the lower lethality, weight loss, clinical signs, and improved histological findings. CD69(+) cells infiltrated extensively into the inflamed mucosa of the colon in WT mice after DSS treatment. Experiments with the transfer of WT CD4 T cells into CD69 KO mice restored the induction of colitis. The administration of an anti-CD69 antibody also inhibited the induction of the DSS-induced colitis. These results indicate that CD69 expressed on CD4 T cells plays an important role in the pathogenesis of DSS-induced acute and chronic colitis, and that CD69 could be a possible therapeutic target for colitis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.