ArticleFrontiers in genetics2013
The complexity, function and applications of RNA in circulation.
Article in Frontiers in genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed.
- An RNase domain-dependent microRNA detection with DNA-spiked nanocage for accurate cancer diagnosis.Nature communications · 2026Article
- RNA-Based Liquid Biopsy in Head and Neck Cancer.Cells · 2023Review
- Nucleic acid liquid biopsies in Alzheimer's disease: current state, challenges, and opportunities.Heliyon · 2022Review
- Isolation of Cell-Free miRNA from Biological Fluids: Influencing Factors and Methods.Diagnostics (Basel, Switzerland) · 2021Review
- Plasma Extracellular Vesicle-Derived TIMP-1 mRNA as a Prognostic Biomarker in Clear Cell Renal Cell Carcinoma: A Pilot Study.International journal of molecular sciences · 2020Article
- The presence of extracellular microRNAs in the media of cultured Drosophila cells.Scientific reports · 2018Article
- Existing and novel biomarkers for precision medicine in systemic sclerosis.Nature reviews. Rheumatology · 2018Review
- miRDis: a Web tool for endogenous and exogenous microRNA discovery based on deep-sequencing data analysis.Briefings in bioinformatics · 2018Article
- MicroRNAs as biomarkers of acute lung injury.Annals of translational medicine · 2018Review
- A next generation sequencing based approach to identify extracellular vesicle mediated mRNA transfers between cells.BMC genomics · 2017Article
- sRNAnalyzer-a flexible and customizable small RNA sequencing data analysis pipeline.Nucleic acids research · 2017Article
- Tiny But Mighty: Promising Roles of MicroRNAs in the Diagnosis and Treatment of Parkinson's Disease.Neuroscience bulletin · 2017Review
- Lysozyme association with circulating RNA, extracellular vesicles, and chronic stress.BBA clinical · 2017Article
- Circulating nucleic acids: An analysis of their occurrence in malignancies.Biomedical reports · 2017Article
- Toward reliable biomarker signatures in the age of liquid biopsies - how to standardize the small RNA-Seq workflow.Nucleic acids research · 2016Article
- Anomalous uptake and circulatory characteristics of the plant-based small RNA MIR2911.Scientific reports · 2016Article
- Evaluation of viremia, proviral load and cytokine profile in naturally feline immunodeficiency virus infected cats treated with two different protocols of recombinant feline interferon omega.Research in veterinary science · 2015Article
- Acute responses of circulating microRNAs to low-volume sprint interval cycling.Frontiers in physiology · 2015Article
- mRNA fragments in in vitro culture media are associated with bovine preimplantation embryonic development.Frontiers in genetics · 2015Article
- Diagnostic and prognostic microRNAs in the serum of breast cancer patients measured by droplet digital PCR.Biomarker research · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood carries a wide array of biomolecules, including nutrients, hormones, and molecules that are secreted by cells for specific biological functions. The recent finding of stable RNA of both endogenous and exogenous origin in circulation raises a number of questions and opens a broad, new field: exploring the origins, functions, and applications of these extracellular RNA molecules. These findings raise many important questions, including: what are the mechanisms of export and cellular uptake, what is the nature and source of their stability, what molecules do they interact with in the blood, and what are the possible biological functions of the circulating RNA? This review summarizes some key recent developments in circulating RNA research and discusses some of the open questions in the field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.