ArticleFrontiers in microbiology2013
Green tea as an effective antimicrobial for urinary tract infections caused by Escherichia coli.
Article in Frontiers in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04024046 (Evaluation of the Impact of the Uqora Dietary Supplement Products on Urinary Tract Infection), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Evaluation of the Impact of the Uqora Dietary Supplement Products on Urinary Tract Infection (UTI) Incidence in Women With Recurring UTIs
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Medicinal plants--prophylactic and therapeutic options for gastrointestinal and respiratory diseases in calves and piglets? A systematic review.BMC veterinary research · 2016Pooled it
- Plant Extracts and Natural Compounds for the Treatment of Urinary Tract Infections in Women: Mechanisms, Efficacy, and Therapeutic Potential.Current issues in molecular biology · 2025Review
- Lactic Acid Bacteria in Vinegar Fermentation: Diversity, Functionality and Health Benefits.Foods (Basel, Switzerland) · 2025Review
- Effects of Different Levels of Green Tea Powder on Performance, Antioxidant Activity, Egg Mass, Quality, and Cecal Microflora of Chickens.Animals : an open access journal from MDPI · 2024Article
- Plant phenolics inhibit focal adhesion kinase and suppress host cell invasion by uropathogenicInfection and immunity · 2024Article
- Analysis of the Antimicrobial Activity of Epigallocatechin-3-Gallate (EGCG).Bulletin of experimental biology and medicine · 2024Article
- Restoring Ampicillin Sensitivity in Multidrug-ResistantJournal of microbiology and biotechnology · 2023Article
- Natural Polyphenols for Prevention and Treatment of Urinary Tract Infections.International journal of molecular sciences · 2023Review
- Is There an Epidemic of Research Fraud in Natural Medicine?Integrative medicine (Encinitas, Calif.) · 2022Article
- Matcha Green Tea Exhibits Bactericidal Activity againstAntibiotics (Basel, Switzerland) · 2021Article
- Prophylactic Catechin-Rich Green Tea Extract Treatment Ameliorates Pathogenic EnterotoxicPathogens (Basel, Switzerland) · 2021Article
- The Impact of Apple Variety and the Production Methods on the Antibacterial Activity of Vinegar Samples.Molecules (Basel, Switzerland) · 2021Article
- Assessment of (-) epicatechin as natural additive for improving safety and functionality in fresh "Piel de Sapo" melon juice.Food science & nutrition · 2021Article
- Article
- Behavioral and dietary risk factors of recurrent urinary tract infection in Chinese postmenopausal women: a case-control study.The Journal of international medical research · 2020Article
- Natural therapeutics for urinary tract infections-a review.Future journal of pharmaceutical sciences · 2020Review
- Alternative Therapeutic Options to Antibiotics for the Treatment of Urinary Tract Infections.Frontiers in microbiology · 2020Review
- UroPathogenicFrontiers in microbiology · 2017Review
- Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?Nature reviews. Drug discovery · 2015Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUrinary tract infections (UTIs) are a very most common type of infection worldwide, and result in billions of dollars in medical care costs. Escherichia coli is the infective agent for 80-90% of all UTIs. Green tea, derived from leaves of the Camellia sinensis plant has been shown to have various potential health benefits (e.g., cardiovascular disease and cancer). The major beneficial components of green tea have been characterized, and are now known to be polyphenolic catechins. The main catechins in green tea are (-)-epicatechin-3-gallate, (-)-epigallocatechin (EGC), (-)-epicatechin, and (-)-epigallocatechin-3-gallate (EGCG). EGCG and EGC have been shown to have the greatest antimicrobial effects, but only EGC has been shown to be excreted in urine. Isolates of E. coli from UTIs collected between 2007 and 2008 were characterized for antimicrobial resistance to standard drugs. Then 80 of these isolates, representing a wide spectrum of antimicrobial susceptibility patterns, were selected for testing using an extract of green tea.
resultsThe concentrations of green tea extract tested were 0, 2.5, 3.0, 3.5, and 4.0 mg/ml. All of the strains tested, except one, had minimum inhibitory concentrations (MICs) of ≤4.0 mg/ml (99%), with 94% of the isolates having an MIC of ≤3.5 mg/ml, 76% of the isolates having an MIC of ≤3.0 mg/ml, 40% of the isolates having an MIC of ≤2.5 mg/ml. Two control strains varied in susceptibility, one having an MIC of ≤2.5 mg/ml,and the other having an MIC of ≤3.5 mg/ml.
conclusionSince EGC has been shown to have antimicrobial effects on E. coli, and EGC has been shown to be excreted in the urine in a high enough concentration to potentially be effective as an antimicrobial; these MIC results suggest that ingesting green tea could have potential antimicrobial effects on UTIs caused by E. coli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.