ArticleFrontiers in physiology2013
Peroxisome degradation in mammals: mechanisms of action, recent advances, and perspectives.
Article in Frontiers in physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Ceria nanoparticles guard against glucocorticoid induced bone homeostasis imbalance through the promotion of osteogenesis and inhibition of osteoclastogenesis.Materials today. Bio · 2025Article
- Whole organism and tissue-specific analysis of pexophagy inOpen biology · 2025Article
- Repurposing degradation pathways for modular metabolite biosynthesis in nematodes.Nature chemical biology · 2023Review
- SCP2 variant is associated with alterations in lipid metabolism, brainstem neurodegeneration, and testicular defects.Human genomics · 2022Article
- USP30: Structure, Emerging Physiological Role, and Target Inhibition.Frontiers in pharmacology · 2022Review
- The Peroxisome-Autophagy Redox Connection: A Double-Edged Sword?Frontiers in cell and developmental biology · 2021Review
- Aging lowers PEX5 levels in cortical neurons in male and female mouse brains.Molecular and cellular neurosciences · 2020Article
- The cell biology of the retinal pigment epithelium.Progress in retinal and eye research · 2020Review
- Peroxisomal Hydrogen Peroxide Metabolism and Signaling in Health and Disease.International journal of molecular sciences · 2019Review
- Deubiquitinating enzyme USP30 maintains basal peroxisome abundance by regulating pexophagy.The Journal of cell biology · 2019Article
- PEX5 regulates autophagy via the mTORC1-TFEB axis during starvation.Experimental & molecular medicine · 2018Article
- Mind the Organelle Gap - Peroxisome Contact Sites in Disease.Trends in biochemical sciences · 2018Review
- Peroxisomes contribute to oxidative stress in neurons during doxorubicin-based chemotherapy.Molecular and cellular neurosciences · 2018Article
- Relevance of autophagy to fatty liver diseases and potential therapeutic applications.Amino acids · 2017Review
- The Peroxisome-Mitochondria Connection: How and Why?International journal of molecular sciences · 2017Review
- Cleaning House: Selective Autophagy of Organelles.Developmental cell · 2017Review
- Aspirin increases mitochondrial fatty acid oxidation.Biochemical and biophysical research communications · 2017Article
- Comparison of Transcriptome Between Type 2 Diabetes Mellitus and Impaired Fasting Glucose.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- PEX2 is the E3 ubiquitin ligase required for pexophagy during starvation.The Journal of cell biology · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peroxisomes are remarkably dynamic organelles that participate in a diverse array of cellular processes, including the metabolism of lipids and reactive oxygen species. In order to regulate peroxisome function in response to changing nutritional and environmental stimuli, new organelles need to be formed and superfluous and dysfunctional organelles have to be selectively removed. Disturbances in any of these processes have been associated with the etiology and progression of various congenital neurodegenerative and age-related human disorders. The aim of this review is to critically explore our current knowledge of how peroxisomes are degraded in mammalian cells and how defects in this process may contribute to human disease. Some of the key issues highlighted include the current concepts of peroxisome removal, the peroxisome quality control mechanisms, the initial triggers for peroxisome degradation, the factors for dysfunctional peroxisome recognition, and the regulation of peroxisome homeostasis. We also dissect the functional and mechanistic relationship between different forms of selective organelle degradation and consider how lysosomal dysfunction may lead to defects in peroxisome turnover. In addition, we draw lessons from studies on other organisms and extrapolate this knowledge to mammals. Finally, we discuss the potential pathological implications of dysfunctional peroxisome degradation for human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.