ArticleFrontiers in neuroscience2013
Perinatal programming of neuroendocrine mechanisms connecting feeding behavior and stress.
Article in Frontiers in neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- Multiome Profiling Reveals Astrocyte and Neuroendocrine Targets of Prenatal Acoustic Programming in Zebra Finch Embryos.bioRxiv : the preprint server for biology · 2026Article
- Contributions of subjective status to eating behaviors, obesity, and metabolic health across development.Appetite · 2025Review
- Long lasting effects of perinatal exposure to the Chlorpyrifos pesticide on sleep, breathing, and neuroinflammation in adult mice.PloS one · 2025Article
- Multiple Early Life Stressors as Risk Factors for Neurodevelopmental Abnormalities in the F1 Wistar Rats.Brain sciences · 2023Article
- Glucocorticoids contribute to metabolic and liver impairments induced by lactation overnutrition in male adult rats.Frontiers in physiology · 2023Article
- Early-life nicotine or cotinine exposure produces long-lasting sleep alterations and downregulation of hippocampal corticosteroid receptors in adult mice.Scientific reports · 2021Article
- Long-term high fat diet consumption reversibly alters feeding behavior via a dopamine-associated mechanism in mice.Behavioural brain research · 2021Article
- Chronic depression-like phenotype in male offspring mice following perinatal exposure to naturally contaminated eels with a mixture of organic and inorganic pollutants.Environmental science and pollution research international · 2021Article
- Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors.Nutrients · 2020Review
- Differential Responses of Liver and Hypothalamus to the Nutritional Condition During Lactation and Adult Life.Frontiers in physiology · 2020Article
- NIPE is related to parasympathetic activity. Is it also related to comfort?Journal of clinical monitoring and computing · 2019Article
- Sex differences in prenatal stress effects on cocaine pursuit in rats.Physiology & behavior · 2019Article
- Gestational Hypoxia and Developmental Plasticity.Physiological reviews · 2018Review
- Effects of Isolation and Social Subchronic Stresses on Food Intake and Levels of Leptin, Ghrelin, and Glucose in Male Rats.Advanced biomedical research · 2018Article
- Offspring neuroimmune consequences of maternal malnutrition: Potential mechanism for behavioral impairments that underlie metabolic and neurodevelopmental disorders.Frontiers in neuroendocrinology · 2017Review
- Where Do Epigenetics and Developmental Origins Take the Field of Developmental Psychopathology?Journal of abnormal child psychology · 2016Article
- Diet, behavior and immunity across the lifespan.Neuroscience and biobehavioral reviews · 2015Review
- Integrated circuits and molecular components for stress and feeding: implications for eating disorders.Genes, brain, and behavior · 2015Review
- The importance of early life in childhood obesity and related diseases: a report from the 2014 Gravida Strategic Summit.Journal of developmental origins of health and disease · 2014Review
- Comparative endocrinology of leptin: assessing function in a phylogenetic context.General and comparative endocrinology · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Feeding behavior is closely regulated by neuroendocrine mechanisms that can be influenced by stressful life events. However, the feeding response to stress varies among individuals with some increasing and others decreasing food intake after stress. In addition to the impact of acute lifestyle and genetic backgrounds, the early life environment can have a life-long influence on neuroendocrine mechanisms connecting stress to feeding behavior and may partially explain these opposing feeding responses to stress. In this review I will discuss the perinatal programming of adult hypothalamic stress and feeding circuitry. Specifically I will address how early life (prenatal and postnatal) nutrition, early life stress, and the early life hormonal profile can program the hypothalamic-pituitary-adrenal (HPA) axis, the endocrine arm of the body's response to stress long-term and how these changes can, in turn, influence the hypothalamic circuitry responsible for regulating feeding behavior. Thus, over- or under-feeding and/or stressful events during critical windows of early development can alter glucocorticoid (GC) regulation of the HPA axis, leading to changes in the GC influence on energy storage and changes in GC negative feedback on HPA axis-derived satiety signals such as corticotropin-releasing-hormone. Furthermore, peripheral hormones controlling satiety, such as leptin and insulin are altered by early life events, and can be influenced, in early life and adulthood, by stress. Importantly, these neuroendocrine signals act as trophic factors during development to stimulate connectivity throughout the hypothalamus. The interplay between these neuroendocrine signals, the perinatal environment, and activation of the stress circuitry in adulthood thus strongly influences feeding behavior and may explain why individuals have unique feeding responses to similar stressors.
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