ArticlePLoS genetics2013
Causes and consequences of chromatin variation between inbred mice.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Article
- Analysis of cis-regulatory changes underlying phenotype divergence shaped by domestication in pigs.Frontiers in genetics · 2024Article
- Article
- Tissue context determines the penetrance of regulatory DNA variation.Nature communications · 2021Article
- A lead candidate functional single nucleotide polymorphism within the WARS2 gene associated with waist-hip-ratio does not alter RNA stability.Biochimica et biophysica acta. Gene regulatory mechanisms · 2020Article
- Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion.Life science alliance · 2019Article
- Sasquatch: predicting the impact of regulatory SNPs on transcription factor binding from cell- and tissue-specific DNase footprints.Genome research · 2017Article
- Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo.Nature cell biology · 2017Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Genetic dissection of the α-globin super-enhancer in vivo.Nature genetics · 2016Article
- An Integrated Genome-Wide Systems Genetics Screen for Breast Cancer Metastasis Susceptibility Genes.PLoS genetics · 2016Article
- Chromatin variation associated with liver metabolism is mediated by transposable elements.Epigenetics & chromatin · 2016Article
- Variation and genetic control of gene expression in primary immunocytes across inbred mouse strains.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Open chromatin profiling in mice livers reveals unique chromatin variations induced by high fat diet.The Journal of biological chemistry · 2014Article
- Lineage and species-specific long noncoding RNAs during erythro-megakaryocytic development.Blood · 2014Article
- Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment.Nature genetics · 2014Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Variation at regulatory elements, identified through hypersensitivity to digestion by DNase I, is believed to contribute to variation in complex traits, but the extent and consequences of this variation are poorly characterized. Analysis of terminally differentiated erythroblasts in eight inbred strains of mice identified reproducible variation at approximately 6% of DNase I hypersensitive sites (DHS). Only 30% of such variable DHS contain a sequence variant predictive of site variation. Nevertheless, sequence variants within variable DHS are more likely to be associated with complex traits than those in non-variant DHS, and variants associated with complex traits preferentially occur in variable DHS. Changes at a small proportion (less than 10%) of variable DHS are associated with changes in nearby transcriptional activity. Our results show that whilst DNA sequence variation is not the major determinant of variation in open chromatin, where such variants exist they are likely to be causal for complex traits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.