ArticlePLoS genetics2013
Distinctive expansion of potential virulence genes in the genome of the oomycete fish pathogen Saprolegnia parasitica.
Article in PLoS genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Who cites it
85 citing papers in PubMed, 195 citations in OpenAlex.
- Eukaryotic metagenome-assembled genomes recovered from deep metagenomic sequencing of the seagrass,Microbial genomics · 2026Article
- How Saprolegniales became successful parasites.PLoS pathogens · 2026Article
- Parasitisterols A-C, 24,25-Dihydroxycholestane-Type Triterpenoids, from Oomycete Fish PathogenACS omega · 2026Article
- Saprolegnia parasitica S1 and S2 Strains Differ in Zoospore Transition Timing and Pathogenicity Against Juvenile Atlantic Salmon (Salmo salar).Journal of fish diseases · 2026Article
- A glimpse into Oomycota diversity in freshwater lakes and adjacent forests using a metabarcoding approach.Scientific reports · 2025Article
- Atypical RXLR effectors are involved inaBIOTECH · 2025Article
- Mitochondrial genome and transcription ofIMA fungus · 2025Article
- Isolation and characterization of Saprolegnia parasitica from cage-reared Pangasianodon hypophthalmus and its sensitivity to different antifungal compounds.Scientific reports · 2024Article
- Correlation Between Effector Gene Expression Targeted by lncRNAs in the Oomycete Fish Pathogen, Saprolegnia parasitica.Marine biotechnology (New York, N.Y.) · 2024Article
- Complete telomere-to-telomere genomes uncover virulence evolution conferred by chromosome fusion in oomycete plant pathogens.Nature communications · 2024Article
- The genome of Salmacisia buchloëana, the parasitic puppet master pulling strings of sexual phenotypic monstrosities in buffalograss.G3 (Bethesda, Md.) · 2024Article
- Description of Saprolegnia velencensis sp. n. (Oomycota), a novel water mold species from Lake Velence, Hungary.PloS one · 2024Article
- MarFERReT, an open-source, version-controlled reference library of marine microbial eukaryote functional genes.Scientific data · 2023Article
- Genome analysis of Parmales, the sister group of diatoms, reveals the evolutionary specialization of diatoms from phago-mixotrophs to photoautotrophs.Communications biology · 2023Article
- Host-pathogen interaction unveiled by immune, oxidative stress, and cytokine expression analysis to experimental Saprolegnia parasitica infection in Nile tilapia.Scientific reports · 2023Article
- Adding a missing piece to the puzzle of oomycete phylogeny: the placement ofFungal systematics and evolution · 2023Article
- Tracing the oomycete pathogen Saprolegnia parasitica in aquaculture and the environment.Scientific reports · 2022Article
- Development of multiplex PCR assay for species-specific detection and identification ofBiotechnology reports (Amsterdam, Netherlands) · 2022Article
- Article
- Saprolegniosis in Amphibians: An Integrated Overview of a Fluffy Killer Disease.Journal of fungi (Basel, Switzerland) · 2022Review
25 more citing papers are in PubMed but not listed here.
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Authors and funding
41 authors at 14 institutions in 8 countries.
Funding
Abstract
Oomycetes in the class Saprolegniomycetidae of the Eukaryotic kingdom Stramenopila have evolved as severe pathogens of amphibians, crustaceans, fish and insects, resulting in major losses in aquaculture and damage to aquatic ecosystems. We have sequenced the 63 Mb genome of the fresh water fish pathogen, Saprolegnia parasitica. Approximately 1/3 of the assembled genome exhibits loss of heterozygosity, indicating an efficient mechanism for revealing new variation. Comparison of S. parasitica with plant pathogenic oomycetes suggests that during evolution the host cellular environment has driven distinct patterns of gene expansion and loss in the genomes of plant and animal pathogens. S. parasitica possesses one of the largest repertoires of proteases (270) among eukaryotes that are deployed in waves at different points during infection as determined from RNA-Seq data. In contrast, despite being capable of living saprotrophically, parasitism has led to loss of inorganic nitrogen and sulfur assimilation pathways, strikingly similar to losses in obligate plant pathogenic oomycetes and fungi. The large gene families that are hallmarks of plant pathogenic oomycetes such as Phytophthora appear to be lacking in S. parasitica, including those encoding RXLR effectors, Crinkler's, and Necrosis Inducing-Like Proteins (NLP). S. parasitica also has a very large kinome of 543 kinases, 10% of which is induced upon infection. Moreover, S. parasitica encodes several genes typical of animals or animal-pathogens and lacking from other oomycetes, including disintegrins and galactose-binding lectins, whose expression and evolutionary origins implicate horizontal gene transfer in the evolution of animal pathogenesis in S. parasitica.
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