ArticlePLoS pathogens2013
Extreme resistance as a host counter-counter defense against viral suppression of RNA silencing.
Article in PLoS pathogens, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Comparative analysis of salicylic acid levels and gene expression in resistant, tolerant, and susceptible cassava varieties following whitefly-mediated SLCMV infection.Scientific reports · 2023Article
- Transcriptome Profiling Reveals a Petunia Transcription Factor,Frontiers in plant science · 2022Article
- Plant defense against virus diseases; growth hormones in highlights.Plant signaling & behavior · 2019Review
- Article
- Review
- MicroRNA-Mediated Gene Silencing in Plant Defense and Viral Counter-Defense.Frontiers in microbiology · 2017Review
- Incomplete Infection of Secondarily Infected Potato Plants - an Environment Dependent Underestimated Mechanism in Plant Virology.Frontiers in plant science · 2017Article
- Article
- Retraction: Extreme Resistance as a Host Counter-counter Defense against Viral Suppression of RNA Silencing.PLoS pathogens · 2015Article
- Roles of plant hormones in the regulation of host-virus interactions.Molecular plant pathology · 2015Review
- Elicitation of hypersensitive responses in Nicotiana glutinosa by the suppressor of RNA silencing protein P0 from poleroviruses.Molecular plant pathology · 2015Article
- RIG-I-dependent antiviral immunity is effective against an RNA virus encoding a potent suppressor of RNAi.Biochemical and biophysical research communications · 2015Article
- The P25 protein of potato virus X (PVX) is the main pathogenicity determinant responsible for systemic necrosis in PVX-associated synergisms.Journal of virology · 2015Article
- Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies.Frontiers in microbiology · 2015Review
- Virus infection triggers widespread silencing of host genes by a distinct class of endogenous siRNAs in Arabidopsis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The conformational and subcellular compartmental dance of plant NLRs during viral recognition and defense signaling.Current opinion in microbiology · 2014Review
- Major QTLs control resistance to rice hoja blanca virus and its vector Tagosodes orizicolus.G3 (Bethesda, Md.) · 2014Article
- Crop immunity against viruses: outcomes and future challenges.Frontiers in plant science · 2014Review
- Identification of the domains of cauliflower mosaic virus protein P6 responsible for suppression of RNA silencing and salicylic acid signalling.The Journal of general virology · 2013Article
- RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence.Nature reviews. Microbiology · 2013Review
Corrections and comments
- Retraction · 2015-09-22Error in Image · Ethical Violations by Author · Investigation by Company/Institution · Manipulation of Images · Plagiarism of Image · · Olivier Voinnet has finding of scientific misconduct http://www2.cnrs.fr/en/2593.htm Patrice Dunoyer named responsible of taking image from student thesis without student's knowledge or consent.
- Retracted
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA silencing mediated by small RNAs (sRNAs) is a conserved regulatory process with key antiviral and antimicrobial roles in eukaryotes. A widespread counter-defensive strategy of viruses against RNA silencing is to deploy viral suppressors of RNA silencing (VSRs), epitomized by the P19 protein of tombusviruses, which sequesters sRNAs and compromises their downstream action. Here, we provide evidence that specific Nicotiana species are able to sense and, in turn, antagonize the effects of P19 by activating a highly potent immune response that protects tissues against Tomato bushy stunt virus infection. This immunity is salicylate- and ethylene-dependent, and occurs without microscopic cell death, providing an example of "extreme resistance" (ER). We show that the capacity of P19 to bind sRNA, which is mandatory for its VSR function, is also necessary to induce ER, and that effects downstream of P19-sRNA complex formation are the likely determinants of the induced resistance. Accordingly, VSRs unrelated to P19 that also bind sRNA compromise the onset of P19-elicited defense, but do not alter a resistance phenotype conferred by a viral protein without VSR activity. These results show that plants have evolved specific responses against the damages incurred by VSRs to the cellular silencing machinery, a likely necessary step in the never-ending molecular arms race opposing pathogens to their hosts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.