ArticlePLoS computational biology2013
Fibrin networks regulate protein transport during thrombus development.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 62 citations in OpenAlex.
- Thrombin-dependent nanoscale architecture and fibrinolytic remodeling of hydrated fibrin clots revealed by expansion microscopy.Journal of thrombosis and haemostasis : JTH · 2026Article
- Functional Aspects of Fibrin Structure Alterations by Tranexamic Acid in the Inhibition of Fibrinolysis.Biomolecules · 2026Article
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- In silico analysis of patient specific coagulation and flow effects on fibrin clot formation.Scientific reports · 2026Article
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- Clots reveal anomalous elastic behavior of fiber networks.Science advances · 2024Article
- Decoding thrombosis through code: a review of computational models.Journal of thrombosis and haemostasis : JTH · 2024Review
- Accessible hotspots for single-protein SERS in DNA-origami assembled gold nanorod dimers with tip-to-tip alignment.Nature communications · 2023Article
- Image-based flow simulation of platelet aggregates under different shear rates.PLoS computational biology · 2023Article
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- A fibrin enhanced thrombosis model for medical devices operating at low shear regimes or large surface areas.PLoS computational biology · 2022Article
- Advantages of Fibrin Polymerization Method without the Use of Exogenous Thrombin for Vascular Tissue Engineering Applications.Biomedicines · 2022Article
- Computational modeling of blood component transport related to coronary artery thrombosis in Kawasaki disease.PLoS computational biology · 2021Article
- A three-dimensional phase-field model for multiscale modeling of thrombus biomechanics in blood vessels.PLoS computational biology · 2020Article
- Article
- In vivo measurement of blood clot mechanics from computational fluid dynamics based on intravital microscopy images.Computers in biology and medicine · 2019Article
- Three-phase Model of Visco-elastic Incompressible Fluid Flow and its Computational Implementation.Communications in computational physics · 2019Article
- Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels.Colloids and surfaces. B, Biointerfaces · 2018Article
- Platelet packing density is an independent regulator of the hemostatic response to injury.Journal of thrombosis and haemostasis : JTH · 2018Article
- Data-driven Modeling of Hemodynamics and its Role on Thrombus Size and Shape in Aortic Dissections.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thromboembolic disease is a leading cause of morbidity and mortality worldwide. In the last several years there have been a number of studies attempting to identify mechanisms that stop thrombus growth. This paper identifies a novel mechanism related to formation of a fibrin cap. In particular, protein transport through a fibrin network, an important component of a thrombus, was studied by integrating experiments with model simulations. The network permeability and the protein diffusivity were shown to be important factors determining the transport of proteins through the fibrin network. Our previous in vivo studies in mice have shown that stabilized non-occluding thrombi are covered by a fibrin network ('fibrin cap'). Model simulations, calibrated using experiments in microfluidic devices and accounting for the permeable structure of the fibrin cap, demonstrated that thrombin generated inside the thrombus was washed downstream through the fibrin network, thus limiting exposure of platelets on the thrombus surface to thrombin. Moreover, by restricting the approach of resting platelets in the flowing blood to the thrombus core, the fibrin cap impaired platelets from reaching regions of high thrombin concentration necessary for platelet activation and limited thrombus growth. The formation of a fibrin cap prevents small thrombi that frequently develop in the absence of major injury in the 60000 km of vessels in the body from developing into life threatening events.
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