ArticlePLoS computational biology2013
Patterns of proliferative activity in the colonic crypt determine crypt stability and rates of somatic evolution.
Article in PLoS computational biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
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- Creation of a spatially complex mucus bilayer on an in vitro colon model.Scientific reports · 2024Article
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- Cooperation of partially-transformed clones: an invisible force behind the early stages of carcinogenesis.Royal Society open science · 2021Article
- Metformin and Probiotics in the Crosstalk between Colitis-Associated Colorectal Cancer and Diabetes in Mice.Cancers · 2020Article
- Regulators of Intestinal Epithelial Migration in Sepsis.Shock (Augusta, Ga.) · 2019Article
- Mitotic and apoptotic activity in colorectal neoplasia.BMC gastroenterology · 2018Article
- Optimizing homeostatic cell renewal in hierarchical tissues.PLoS computational biology · 2018Article
- Power of screening tests for colorectal cancer enhanced by high levels of M2-PK in addition to FOBT.Internal and emergency medicine · 2017Article
- Linking Gut Microbiota to Colorectal Cancer.Journal of Cancer · 2017Review
- The role of cell location and spatial gradients in the evolutionary dynamics of colon and intestinal crypts.Biology direct · 2016Article
- Colorectal Carcinoma and Emerging Targeted Therapies.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2015Article
- Cancer evolution: mathematical models and computational inference.Systematic biology · 2015Review
- Colorectal carcinogenesis--update and perspectives.World journal of gastroenterology · 2014Review
- Robustness of differentiation cascades with symmetric stem cell division.Journal of the Royal Society, Interface · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Epithelial cells in the colon are arranged in cylindrical structures called crypts in which cellular proliferation and migration are tightly regulated. We hypothesized that the proliferation patterns of cells may determine the stability of crypts as well as the rates of somatic evolution towards colorectal tumorigenesis. Here, we propose a linear process model of colonic epithelial cells that explicitly takes into account the proliferation kinetics of cells as a function of cell position within the crypt. Our results indicate that proliferation kinetics has significant influence on the speed of cell movement, kinetics of mutation propagation, and sensitivity of the system to selective effects of mutated cells. We found that, of all proliferation curves tested, those with mitotic activities concentrated near the stem cell, including the actual proliferation kinetics determined in in vivo labeling experiments, have a greater ability of delaying the rate of mutation accumulation in colonic stem cells compared to hypothetical proliferation curves with mitotic activities focused near the top of the crypt column. Our model can be used to investigate the dynamics of proliferation and mutation accumulation in spatially arranged tissues.
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Registered trials
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