Evidence map›Paper›PMID 23785210›Full record

ArticleJournal of virology2013

Secondary infections, expanded tissue tropism, and evidence for malignant potential in immunocompromised mice infected with Mus musculus papillomavirus 1 DNA and virus.

Nancy M Cladel, Lynn R Budgeon, Timothy K Cooper, Karla K Balogh, Jiafen Hu, Neil D Christensen

Open access · bronzeAbstract read
In one paragraph

Article in Journal of virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 66 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nancy M CladelJake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
Lynn R Budgeon
Timothy K Cooper
Karla K Balogh
Jiafen Hu
Neil D Christensen
Cancer Research Foundation · USPennsylvania State University · US

Funding

Papillomavirus Host InterationR01CA047622 · NCI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRISTENSEN, NEIL D · 1988 to 2015
$3.8M
Role of estrous cycle and contraceptives in anogenital papillomavirus infectionR21AI121822 · NIAID · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI CHRISTENSEN, NEIL D, HU, JIAFEN · 2016 to 2017
$425k
NCI NIH HHS R01 CA047622NIAID NIH HHS R21 AI121822
6 · The paper itself

Abstract

Papillomavirus disease poses a special challenge to people with compromised immune systems. Appropriate models to study infections in these individuals are lacking. We report here the development of a model that will help to address these deficiencies. The MmuPV1 genome was synthesized and used successfully to produce virus from DNA infections in immunocompromised mice. In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia.

Indexed as

Cell Transformation, NeoplasticViral TropismAnimalsDisease Models, AnimalDNA, ViralFemaleHistocytochemistryImmunocompromised HostMiceMice, NudeNeckPapillomaviridaePapillomavirus InfectionsSkinTransduction, GeneticTransformation, GeneticDNA, Viral

Identifiers

PMID23785210
PMCPMC3754027
OpenAlexW2154723551

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.