ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
The extracellular matrix glycoprotein tenascin-R affects adult but not developmental neurogenesis in the olfactory bulb.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Reconciling the neurogenic hypothesis of depression with recent advances in adult hippocampal neurogenesis research in humans.Molecular psychiatry · 2026Review
- Role of Matricellular Proteins in Endothelial Cell Inflammation and Atherosclerosis.Antioxidants (Basel, Switzerland) · 2025Review
- Signaling mechanisms underlying activity-dependent integration of adult-born neurons in the mouse olfactory bulb.Genesis (New York, N.Y. : 2000) · 2024Review
- Development of the mammalian main olfactory bulb.Development (Cambridge, England) · 2022Review
- The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Defining the Adult Neural Stem Cell Niche Proteome Identifies Key Regulators of Adult Neurogenesis.Cell stem cell · 2020Article
- Distribution and classification of the extracellular matrix in the olfactory bulb.Brain structure & function · 2020Article
- Early Days of Tenascin-R Research: Two Approaches Discovered and Shed Light on Tenascin-R.Frontiers in immunology · 2020Article
- Intrinsic Mechanisms Regulating Neuronal Migration in the Postnatal Brain.Frontiers in cellular neuroscience · 2020Review
- Determination of the connectivity of newborn neurons in mammalian olfactory circuits.Cellular and molecular life sciences : CMLS · 2017Review
- The Role of Adult-Born Neurons in the Constantly Changing Olfactory Bulb Network.Neural plasticity · 2016Review
- Mimicking Neural Stem Cell Niche by Biocompatible Substrates.Stem cells international · 2016Review
- Downregulation of Sphingosine 1-Phosphate Receptor 1 Promotes the Switch from Tangential to Radial Migration in the OB.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Interaction between Neurogenesis and Hippocampal Memory System: New Vistas.Cold Spring Harbor perspectives in biology · 2015Review
- Molecular Mechanisms Regulating the Dendritic Development of Newborn Olfactory Bulb Interneurons in a Sensory Experience-Dependent Manner.Frontiers in neuroscience · 2015Review
- Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Physiological genomics · 2014Article
- Extracellular matrix control of dendritic spine and synapse structure and plasticity in adulthood.Frontiers in neuroanatomy · 2014Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Neuronal precursors produced in the subventricular zone throughout an animal's life migrate tangentially along the rostral migratory stream and, once in the olfactory bulb (OB), turn to migrate radially to the bulbar layers, where they differentiate into interneurons. Despite extensive investigations, it has remained largely unknown whether the same molecular mechanisms control OB neurogenesis during early postnatal development and in adulthood. In this study, we show that the extracellular matrix glycoprotein tenascin-R (TNR) is produced in the granule cell layer of the OB and that its expression increases during postnatal development. Time-lapse video imaging and morphological analyses revealed that a lack of TNR decreases the radial migration of neuronal precursors in the adult, but not in the developing OB. A lack of TNR also reduces spine development of newborn neurons in adult mice. To understand the functional consequences of a lack of TNR, we performed electrophysiological and behavioral studies on young and adult mice. Electrophysiological recordings showed that mitral cells, the target cells of newly generated interneurons, receive reduced spontaneous and evoked inhibitory activity in adult, but not young, TNR knock-out mice. Moreover, the synchronized activity of mitral cells was decreased in the OB of adult TNR knock-out mice. Behavioral studies revealed that the lower numbers of newborn interneurons in the adult OB induce alterations in short-term odor memory. Our results indicate that TNR modulates adult but not developmental neurogenesis in the OB and also highlight that the regulation of OB neurogenesis can vary during an animal's lifetime.
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