ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2013
Reward-modulated motor information in identified striatum neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers.
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Who cites it
89 citing papers in PubMed, 172 citations in OpenAlex.
- Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions.Science advances · 2026Article
- Temporally Coordinated Activity among Motor Cortex, Thalamus, and Thalamic Reticular Nucleus Neurons during Rat Forelimb Movements.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Frontal-striatal-thalamic circuit dysfunction and inferential processing between internal representations and external events across the psychosis spectrum.Frontiers in psychiatry · 2026Review
- Shared striatal neurons exhibit context-specific dynamics for internally and externally driven actions.bioRxiv : the preprint server for biology · 2025Article
- Refinement of efficient encodings of movement in the dorsolateral striatum throughout learning.Cell reports · 2025Article
- Behavioral inflexibility through overtraining is mediated by reduced mGluR1/5 signaling capacity in the dorsolateral striatum.PLoS biology · 2025Article
- Hippocampal Sharp-Wave Ripples Decrease during Physical Actions Including Consummatory Behavior in Immobile Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Direct and indirect striatal projecting neurons exert strategy-dependent effects on decision-making.Science advances · 2025Article
- Reward expectation and receipt differentially modulate the spiking of accumbens D1+ and D2+ neurons.Current biology : CB · 2025Article
- Cell-type-specific auditory responses in the striatum are shaped by feedforward inhibition.Cell reports · 2025Article
- Striosomes control dopamine via dual pathways paralleling canonical basal ganglia circuits.Current biology : CB · 2024Article
- Investigating changes in the premotor cortex-derived frontal-striatal-thalamic subcircuit in attenuated psychosis syndrome.Brain imaging and behavior · 2024Article
- Striosomes Target Nigral Dopamine-Containing Neurons via Direct-D1 and Indirect-D2 Pathways Paralleling Classic Direct-Indirect Basal Ganglia Systems.bioRxiv : the preprint server for biology · 2024Article
- Globus pallidus is not independent from striatal direct pathway neurons: an up-to-date review.Molecular brain · 2024Review
- Article
- The Secondary Motor Cortex-striatum Circuit Contributes to Suppressing Inappropriate Responses in Perceptual Decision Behavior.Neuroscience bulletin · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.eLife · 2023Article
- Reward expectation enhances action-related activity of nigral dopaminergic and two striatal output pathways.Communications biology · 2023Article
- Multiple dynamic interactions from basal ganglia direct and indirect pathways mediate action selection.bioRxiv : the preprint server for biology · 2023Article
- Rat hippocampal CA1 region represents learning-related action and reward events with shorter latency than the lateral entorhinal cortex.Communications biology · 2023Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely accepted that dorsal striatum neurons participate in either the direct pathway (expressing dopamine D1 receptors) or the indirect pathway (expressing D2 receptors), controlling voluntary movements in an antagonistically balancing manner. The D1- and D2-expressing neurons are activated and inactivated, respectively, by dopamine released from substantia nigra neurons encoding reward expectation. However, little is known about the functional representation of motor information and its reward modulation in individual striatal neurons constituting the two pathways. In this study, we juxtacellularly recorded the spike activity of single neurons in the dorsolateral striatum of rats performing voluntary forelimb movement in a reward-predictable condition. Some of these neurons were identified morphologically by a combination of juxtacellular visualization and in situ hybridization for D1 mRNA. We found that the striatal neurons exhibited distinct functional activations before and during the forelimb movement, regardless of the expression of D1 mRNA. They were often positively, but rarely negatively, modulated by expecting a reward for the correct motor response. The positive reward modulation was independent of behavioral differences in motor performance. In contrast, regular-spiking and fast-spiking neurons in any layers of the motor cortex displayed only minor and unbiased reward modulation of their functional activation in relation to the execution of forelimb movement. Our results suggest that the direct and indirect pathway neurons cooperatively rather than antagonistically contribute to spatiotemporal control of voluntary movements, and that motor information is subcortically integrated with reward information through dopaminergic and other signals in the skeletomotor loop of the basal ganglia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.