ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2013
Enhanced NMDA receptor-mediated intracellular calcium signaling in magnocellular neurosecretory neurons in heart failure rats.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Endoplasmic Reticulum and Mitochondrial Calcium Handling Dynamically Shape Slow Afterhyperpolarizations in Vasopressin Magnocellular Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Angiotensin II-Mediated Neuroinflammation in the Hippocampus Contributes to Neuronal Deficits and Cognitive Impairment in Heart Failure Rats.Hypertension (Dallas, Tex. : 1979) · 2023Article
- Article
- Angiotensin II inhibits the A-type KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- α-Melanocyte-stimulating hormone inhibition of oxytocin neurons switches to excitation in late pregnancy and lactation.Physiological reports · 2022Article
- Heart failure impairs mood and memory in male rats and down-regulates the expression of numerous genes important for synaptic plasticity in related brain regions.Behavioural brain research · 2021Article
- Functional coupling between NMDA receptors and SK channels in rat hypothalamic magnocellular neurons: altered mechanisms during heart failure.The Journal of physiology · 2021Article
- Somato-dendritic vasopressin and oxytocin secretion in endocrine and autonomic regulation.Journal of neuroendocrinology · 2020Review
- Maternal Gastrointestinal Nematode Infection Up-regulates Expression of Genes Associated with Long-Term Potentiation in Perinatal Brains of Uninfected Developing Pups.Scientific reports · 2019Article
- NMDA receptors potentiate activity-dependent dendritic release of neuropeptides from hypothalamic neurons.The Journal of physiology · 2019Article
- A reduction in SK channels contributes to increased activity of hypothalamic magnocellular neurons during heart failure.The Journal of physiology · 2017Article
- Integration of renal sensory afferents at the level of the paraventricular nucleus dictating sympathetic outflow.Autonomic neuroscience : basic & clinical · 2017Review
- The effects of verapamil and its combinations with glutamate and glycine on cardiodynamics, coronary flow and oxidative stress in isolated rat heart.Journal of physiology and biochemistry · 2017Article
- Dendritic Release of Neurotransmitters.Comprehensive Physiology · 2016Review
- Mechanisms underlying prorenin actions on hypothalamic neurons implicated in cardiometabolic control.Molecular metabolism · 2016Article
- Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Neuroendocrine-autonomic integration in the paraventricular nucleus: novel roles for dendritically released neuropeptides.Journal of neuroendocrinology · 2015Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
An enhanced glutamate excitatory function within the hypothalamic supraoptic and paraventricluar nuclei is known to contribute to increased neurosecretory and presympathetic neuronal activity, and hence, neurohumoral activation, during heart failure (HF). Still, the precise mechanisms underlying enhanced glutamate-driven neuronal activity in HF remain to be elucidated. Here, we performed simultaneous electrophysiology and fast confocal Ca²⁺ imaging to determine whether altered N-methyl-d-aspartate (NMDA) receptor-mediated changes in intracellular Ca²⁺ levels (NMDA-ΔCa²⁺) occurred in hypothalamic magnocellular neurosecretory cells (MNCs) in HF rats. We found that activation of NMDA receptors resulted in a larger ΔCa²⁺ in MNCs from HF when compared with sham rats. The enhanced NMDA-ΔCa²⁺ was neither dependent on the magnitude of the NMDA-mediated current (voltage clamp) nor on the degree of membrane depolarization or firing activity evoked by NMDA (current clamp). Differently from NMDA receptor activation, firing activity evoked by direct membrane depolarization resulted in similar changes in intracellular Ca²⁺ in sham and HF rats. Taken together, our results support a relatively selective alteration of intracellular Ca²⁺ homeostasis and signaling following activation of NMDA receptors in MNCs during HF. The downstream functional consequences of such altered ΔCa²⁺ signaling during HF are discussed.
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