ArticleProceedings of the National Academy of Sciences of the United States of America2013
Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Single-cell transcriptomic profiling of C. elegans Q neuroblast lineage during migration and differentiation.PloS one · 2026Article
- Single-cell transcriptomic profiling ofbioRxiv : the preprint server for biology · 2025Article
- Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo.Nature communications · 2025Article
- Article
- MAB-5/Hox regulates the Q neuroblast transcriptome, including cwn-1/Wnt, to mediate posterior migration in Caenorhabditis elegans.Genetics · 2024Article
- MAB-5/Hox regulates the Q neuroblast transcriptome, includingbioRxiv : the preprint server for biology · 2023Article
- Nervous system-wide analysis of Hox regulation of terminal neuronal fate specification in Caenorhabditis elegans.PLoS genetics · 2022Article
- A switch from noncanonical to canonical Wnt signaling stops neuroblast migration through a Slt-Robo and RGA-9b/ARHGAP-dependent mechanism.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Emerging Roles for Hox Proteins in the Last Steps of Neuronal Development in Worms, Flies, and Mice.Frontiers in neuroscience · 2021Review
- Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABANature communications · 2020Article
- Article
- Necessity and Contingency in Developmental Genetic Screens: EGF, Wnt, and Semaphorin Pathways in Vulval Induction of the NematodeGenetics · 2019Article
- Cargo crowding at actin-rich regions along axons causes local traffic jams.Traffic (Copenhagen, Denmark) · 2018Article
- Article
- Hippo kinases maintain polarity during directional cell migration in Caenorhabditis elegans.The EMBO journal · 2017Article
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- Functional Roles of the Interaction of APP and Lipoprotein Receptors.Frontiers in molecular neuroscience · 2017Review
- Article
- EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans.PloS one · 2016Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Directional cell migration is a fundamental process in neural development. In Caenorhabditis elegans, Q neuroblasts on the left (QL) and right (QR) sides of the animal generate cells that migrate in opposite directions along the anteroposterior body axis. The homeobox (Hox) gene lin-39 promotes the anterior migration of QR descendants (QR.x), whereas the canonical Wnt signaling pathway activates another Hox gene, mab-5, to ensure the QL descendants' (QL.x) posterior migration. However, the regulatory targets of LIN-39 and MAB-5 remain elusive. Here, we showed that MIG-13, an evolutionarily conserved transmembrane protein, cell-autonomously regulates the asymmetric distribution of the actin cytoskeleton in the leading migratory edge. We identified mig-13 as a cellular target of LIN-39 and MAB-5. LIN-39 establishes QR.x anterior polarity by binding to the mig-13 promoter and promoting mig-13 expression, whereas MAB-5 inhibits QL.x anterior polarity by associating with the lin-39 promoter and downregulating lin-39 and mig-13 expression. Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.