ArticleLiver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society2013
Impact of the center on graft failure after liver transplantation.
Article in Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effect of adjuvant use of metformin on periodontal treatment: a systematic review and meta-analysis.Clinical oral investigations · 2019Pooled it
- FERI: A Multitask-based Fairness Achieving Algorithm with Applications to Fair Organ Transplantation.AMIA Joint Summits on Translational Science proceedings. AMIA Joint Summits on Translational Science · 2024Article
- Liver retransplants using living donors: An approach for management.Liver research (Beijing, China) · 2023Article
- The association of center volume with transplant outcomes in selected high-risk groups in kidney transplantation.BMC nephrology · 2023Article
- Textbook Outcome Following Liver Transplantation.World journal of surgery · 2021Article
- No Benefit of Prophylactic Surgical Drainage in Combined Liver and Kidney Transplantation: Our Experience and Review of the Literature.Frontiers in surgery · 2021Article
- Simultaneous Liver Kidney Transplant in Elderly Patients With Chronic Kidney Disease: Is There an Appropriate Upper Age Cutoff?Transplantation · 2020Article
- The Impact of Implantation Time During Liver Transplantation on Outcome: A Eurotransplant Cohort Study.Transplantation direct · 2018Article
- Transplant Center Volume and the Risk of Pancreas Allograft Failure.Transplantation · 2017Article
- The Impact of the Share 35 Policy on Racial and Ethnic Disparities in Access to Liver Transplantation for Patients with End Stage Liver Disease in the United States: An Analysis from UNOS Database.International journal for equity in health · 2017Article
- Liver transplantation in Central Europe.Clinical and experimental hepatology · 2016Article
- The prediction accuracy of dynamic mixed-effects models in clustered data.BioData mining · 2016Article
- Survival outcomes in liver transplant recipients with Model for End-stage Liver Disease scores of 40 or higher: a decade-long experience.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2015Article
- Beyond the NIH Multicenter HIV Transplant Trial Experience: Outcomes of HIV+ Liver Transplant Recipients Compared to HCV+ or HIV+/HCV+ Coinfected Recipients in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Article
- Early post-transplant survival: Interaction of MELD score and hospitalization status.Journal of hepatology · 2015Article
- Model for end-stage liver disease score and MELD exceptions: 15 years later.Hepatology international · 2015Review
- Superior survival using living donors and donor-recipient matching using a novel living donor risk index.Hepatology (Baltimore, Md.) · 2014Article
- Development of organ-specific donor risk indices.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2012Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The hospital at which liver transplantation (LT) is performed has a substantial impact on post-LT outcomes. Center-specific outcome data are closely monitored not only by the centers themselves but also by patients and government regulatory agencies. However, the true magnitude of this center effect, apart from the effects of the region and donor service area (DSA) as well as recipient and donor determinants of graft survival, has not been examined. We analyzed data submitted to the Organ Procurement and Transplantation Network for all adult (age ≥ 18 years) primary LT recipients (2005-2008). Using a mixed effects, proportional hazards regression analysis, we modeled graft failure within 1 year after LT on the basis of center (de-identified), region, DSA, and donor and recipient characteristics. At 115 unique centers, 14,654 recipients underwent transplantation. Rates of graft loss within a year varied from 5.9% for the lowest quartile of centers to 20.2% for the highest quartile. Gauged by a comparison of the 75th and 25th percentiles of the data, the magnitude of the center effect on graft survival (1.49-fold change) was similar to that of the recipient Model for End-Stage Liver Disease (MELD) score (1.47) and the donor risk index (DRI; 1.45). The center effect was similar across the DRI and MELD score quartiles and was not associated with a center's annual LT volume. After stratification by region and DSA, the magnitude of the center effect, though decreased, remained significant and substantial (1.30-fold interquartile difference). In conclusion, the LT center is a significant predictor of graft failure that is independent of region and DSA as well as donor and recipient characteristics.
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