ArticleJournal of bone and mineral metabolism2014
Bone mineral density in statin users: a population-based analysis from a Spanish cohort.
Article in Journal of bone and mineral metabolism, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- Relationship between spinal osteoarthritis and vertebral fractures in men older than 50 years: data from the Camargo Cohort Study.Journal of bone and mineral metabolism · 2017Trial
- Trial
- Calcium Blood Level Elevation After Atorvastatin Initiation in a Patient With Hyperparathyroidism.Cureus · 2024Article
- Association between serum lipid profile, body mass index and osteoporosis in postmenopausal Sudanese women.African health sciences · 2022Article
- Effects of hyperlipidemia on trabecular and cortical structures of the mandible.Dento maxillo facial radiology · 2022Article
- Role of Metabolism in Bone Development and Homeostasis.International journal of molecular sciences · 2020Review
- Bone in heart failure.Journal of cachexia, sarcopenia and muscle · 2020Review
- Association Between Bone Mineral Density and Lipid Profile in Chinese Women.Clinical interventions in aging · 2020Article
- Modulation of Bone and Marrow Niche by Cholesterol.Nutrients · 2019Review
- Association Between Bone Mineral Density, Bone Turnover Markers, and Serum Cholesterol Levels in Type 2 Diabetes.Frontiers in endocrinology · 2018Article
- Prevalence of vertebral fracture and densitometric osteoporosis in Spanish adult men: The Camargo Cohort Study.Journal of bone and mineral metabolism · 2018Article
- Orally administered simvastatin partially preserves lumbar vertebral bone mass but not integrity of intervertebral discs in ovariectomized rats.Experimental and therapeutic medicine · 2017Article
- Association of lipid profile with bone mineral density in postmenopausal women in Yazd province.International journal of reproductive biomedicine · 2016Article
- Ischemic heart disease is associated with lower cortical volumetric bone mineral density of distal radius.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2015Article
- Novel applications of statins for bone regeneration.National science review · 2015Article
- Is lipid profile associated with bone mineral density and bone formation in subjects with spinal cord injury?Journal of osteoporosis · 2014Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We studied 2,315 subjects (1,422 women and 893 men) from the Camargo Cohort and analyzed the differences in BMD between statin or non-statin users. We also studied effects of the type of statin, dose, pharmacokinetic properties, and length of treatment on bone mineral density (BMD). Of the subjects, 478 (21 %) were taking statins (256 women and 222 men). Overall, they had higher BMD than non-users (p < 0.0001). In adjusted multivariate models, women taking statins had higher BMD at femoral neck (p = 0.002) and total hip (p = 0.04) than non- users. No differences were found in men. Women taking simvastatin had higher increases in BMD than non-statin users at femoral neck (p = 0.02) and total hip (p = 0.009), those taking fluvastatin had lower BMD values at lumbar spine (p = 0.028), and those receiving lovastatin had higher increases at femoral neck (p = 0.006). In men, only atorvastatin was associated with higher femoral neck BMD than non-statin use (p = 0.029). Comparing with non-statin users, only women receiving lipophilic statins had greater BMD at femoral neck (p = 0.003). According to drug potency, women on high- or lower-potency agents showed higher BMD values at femoral neck than non-users (p = 0.028 and 0.022, respectively). In men, only high-potency statins were associated with higher femoral neck BMD than non-use (p = 0.021). No differences between dose or length of statin therapy were noted regarding BMD in either sex. In summary, in a large population-based cohort, women on statins had higher BMD at the hip than non-users. Overall, this increase in BMD was more evident in subjects on lipophilic or high-potency statins.
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