ArticleThe Journal of general virology2013
Recent host-shifts in ranaviruses: signatures of positive selection in the viral genome.
Article in The Journal of general virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- IVCDB: a comprehensive database of iridoviruses for epidemiology, genetic evolution, and disease management.Nucleic acids research · 2026Article
- Continent-Wide Distribution of CMTV-Like Ranavirus, from the Urals to the Atlantic Ocean.EcoHealth · 2025Article
- Article
- Emerging threat of ranavirus: prevalence, genetic diversity, and climatic drivers ofFrontiers in veterinary science · 2023Article
- Viruses Infecting the European Catfish (Viruses · 2021Review
- Genome analysis of Ranavirus frog virus 3 isolated from American Bullfrog (Lithobates catesbeianus) in South America.Scientific reports · 2019Article
- Fitter frogs from polluted ponds: The complex impacts of human-altered environments.Evolutionary applications · 2019Article
- Ranavirus genotypes in the Netherlands and their potential association with virulence in water frogs (Pelophylax spp.).Emerging microbes & infections · 2018Article
- Divergent transcriptomic responses underlying the ranaviruses-amphibian interaction processes on interspecies infection of Chinese giant salamander.BMC genomics · 2018Article
- Host association and selection on salivary protein genes in bed bugs and related blood-feeding ectoparasites.Royal Society open science · 2017Article
- Co-Infection by Chytrid Fungus and Ranaviruses in Wild and Harvested Frogs in the Tropical Andes.PloS one · 2016Article
- Comparative Genomics of an Emerging Amphibian Virus.G3 (Bethesda, Md.) · 2015Article
- Comparative Genomics of Amphibian-like Ranaviruses, Nucleocytoplasmic Large DNA Viruses of Poikilotherms.Evolutionary bioinformatics online · 2015Article
- Phylogeny and differentiation of reptilian and amphibian ranaviruses detected in Europe.PloS one · 2015Article
- Inflammation-induced reactivation of the ranavirus Frog Virus 3 in asymptomatic Xenopus laevis.PloS one · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Ranaviruses have been implicated in recent declines in global amphibian populations. Compared with the family Iridoviridae, to which the genus Ranavirus belongs, ranaviruses have a wide host range in that species/strains are known to infect fish, amphibians and reptiles, presumably due to recent host-switching events. We used eight sequenced ranavirus genomes and two selection-detection methods (site based and branch based) to identify genes that exhibited signatures of positive selection, potentially due to the selective pressures at play during host switching. We found evidence of positive selection acting on four genes via the site-based method, three of which were newly acquired genes unique to ranavirus genomes. Using the branch-based method, we identified eight additional candidate genes that exhibited signatures of dN/dS (non-synonymous/synonymous substitution rate) >1 in the clade where intense host switching had occurred. We found that these branch-specific patterns of elevated dN/dS were enriched in a small group of viral genes that have been acquired most recently in the ranavirus genome, compared with core genes that are shared among all members of the family Iridoviridae. Our results suggest that the group of newly acquired genes in the ranavirus genome may have undergone recent adaptive changes that have facilitated interspecies and interclass host switching.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.