Evidence map›Paper›PMID 23783531›Full record

SynthesisKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2014

Periarticular multimodal drug injection in total knee arthroplasty.

Yuanjun Teng, Jin Jiang, Shaolong Chen, Lianggong Zhao, Zhaohui Cui, Md Shahidur Khan, Wenjia Du, Xuren Gao, Jing Wang, Yayi Xia

2 registry-linked trialsAbstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
5.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02276495 nacompletednot on this mapstarted 2015, after this paper: background citation

Does Single Injection Adductor Canal Block Improve Postoperative Analgesia in Patients Receiving Periarticular Local Anesthesia Injections for Total Knee Arthroplasty?

TypeinterventionalSponsorUniversity of California, IrvineRan2015 to 2024Enrolled55ConditionsPain ManagementArmsACB Control - 20 ml saline injection for ACB, ACB Study - 20 ml 0.5% Ropivacaine for Adductor Canal Block, Local infiltration - 100 mLs of a solution containing: Ropivacaine + Epinephrine + Ketorolac + Clonidine + 0.9% Normal saline
NCT02420951 nacompletednot on this mapstarted 2015, after this paper: background citation

Local Injection of Local Anesthetic 24 Hours After Knee Replacement Surgery

TypeinterventionalSponsorBrigham and Women's HospitalRan2015 to 2016Enrolled50ConditionsArthroplasty, Knee, PainArmsBupivacaine, No Intervention
3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. [Effect of adductor canal block combined with local infiltration anesthesia on rehabilitation of primary total knee arthroplasty].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2018
    Trial
  7. Trial
  8. Trial
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuanjun TengOrthopaedics Key Laboratory of Gansu Province, The Second Hospital of Lanzhou University, Lanzhou University, No. 82 Cuiyingmen, Chengguan District, Lanzhou City, 730030, Gansu Province, People's Republic of China, tengyj06@126.com.
Jin Jiang
Shaolong Chen
Lianggong Zhao
Zhaohui Cui
Md Shahidur Khan
Wenjia Du
Xuren Gao
Jing Wang
Yayi Xia
Lanzhou University · CNLanzhou University Second Hospital · CNXuzhou Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeA systematic review and meta-analysis based on randomized controlled trials (RCTs) were conducted to evaluate the efficiency and safety of periarticular multimodal drug injection in total knee arthroplasty (TKA).

methodsPeriarticular injection with the use of multimodal drugs is an efficient alternative for postoperative analgesia in TKA. A systematical electronic search was performed to identify the eligible RCTs in the databases of PubMed, Embase, Cochrane Central Register of Controlled Trials, Web of Science and the Chinese Biomedical Literature Database. Two independent reviewers completed data collection and assessment of methodological quality. The quality of evidence of outcomes was judged using GRADE criteria. Meta-analysis was performed for the outcomes of pain, straight leg raise, operating time, hospital stay and complications.

resultsTen RCTs including eight studies with 1,216 TKAs in 835 patients met the inclusion criteria. Periarticular injection with multimodal drugs in TKA was associated with short-term benefits in terms of pain relief, straight leg raise, narcotic consumption, and the rates of nausea, vomiting, rash and pruritus. There were no statistically significant differences in operating time, hospital stay, wound complications and deep vein thrombosis between both groups.

conclusionsThe current evidence suggests that periarticular multimodal drug injection in TKA provides short-term advantages in pain relief, straight leg raise and postoperative complications.

Indexed as

Arthroplasty, Replacement, KneeAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalArthralgiaEpinephrineGlucocorticoidsHumansInjections, Intra-ArticularPain ManagementPostoperative PainRandomized Controlled Trials as TopicTreatment OutcomeAnalgesics, OpioidAnesthetics, LocalAnti-Inflammatory Agents, Non-SteroidalEpinephrineGlucocorticoids

Identifiers

PMID23783531
OpenAlexW1989500227

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.