ArticlePediatric research2013
Placental miRNA expression profiles are associated with measures of infant neurobehavioral outcomes.
Article in Pediatric research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Prenatal pyrethroid exposure, placental gene network modules, and neonatal neurobehavior.International journal of hygiene and environmental health · 2025Article
- Neuroactive steroid exposure impacts neurodevelopment: Comparison of human and rodent placental contribution.Journal of neuroendocrinology · 2025Review
- The Placental Steroid Hypothesis of Human Brain Evolution.Evolutionary anthropology · 2025Review
- Prenatal dexamethasone exposure impairs rat blood-testis barrier function and sperm quality in adult offspring via GR/KDM1B/FSTL3/TGFβ signaling.Acta pharmacologica Sinica · 2024Article
- Human placental microRNAs dysregulated by cadmium exposure predict neurobehavioral outcomes at birth.Pediatric research · 2023Article
- Article
- Selenium-associated differentially expressed microRNAs and their targeted mRNAs across the placental genome in two U.S. birth cohorts.Epigenetics · 2022Observational
- The placenta epigenome-brain axis: placental epigenomic and transcriptomic responses that preprogram cognitive impairment.Epigenomics · 2022Article
- Epigenetics of pregnancy: looking beyond the DNA code.Journal of assisted reproduction and genetics · 2022Review
- The placenta-brain-axis.Journal of neuroscience research · 2021Review
- Article
- Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes.Seminars in fetal & neonatal medicine · 2020Review
- Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health.Environment international · 2019Article
- Sex-specific associations between telomere length and candidate miRNA expression in placenta.Journal of translational medicine · 2018Article
- Review
- Article
- Epigenetic Inheritance: Concepts, Mechanisms and Perspectives.Frontiers in molecular neuroscience · 2018Article
- Mother's Pre-pregnancy BMI and Placental Candidate miRNAs: Findings from the ENVIRONAGE Birth Cohort.Scientific reports · 2017Article
- Neurodevelopmental Disorders and Environmental Toxicants: Epigenetics as an Underlying Mechanism.International journal of genomics · 2017Review
- Pulmonary microRNA profiling: implications in upper lobe predominant lung disease.Clinical epigenetics · 2017Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundA growing body of research suggests that the intrauterine environment influences fetal neurodevelopment by altering the functional placental epigenome. A number of microRNAs (miRNAs) are expressed in the placenta, may be sensitive to dysregulation by environmental exposures, and are associated with adverse pregnancy outcomes. Our study aimed to identify the relationships between placental miRNA expression and newborn neurobehavior.
methodsWe examined the association between the expression of miR-16, miR-21, miR-93, miR-135b, miR-146a, and miR-182 in total RNA from the placentas of 86 term infants as measured by quantitative real-time PCR and newborn neurobehavioral outcomes as assessed using the NICU Network Neurobehavioral Scales (NNNS).
resultsBivariate analysis revealed that placental miR-16 expression is negatively associated with attention score (P = 0.006), whereas expressions of both miR-146a and miR-182 are positively associated with quality of movement score (P = 0.016 and P = 0.016, respectively). Controlling for potential confounders, high miR-16 expression is significantly associated with reduced attention score (P = 0.04), and high miR-146a and miR-182 expressions are significantly associated with increased quality of movement score (P = 0.04 and P = 0.01, respectively).
conclusionThese results suggest that placental miRNA expression is associated with early neurobehavioral outcomes and miRNAs in the placenta may contribute to the developmental origins of infant neurobehavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.