ArticleThe American journal of clinical nutrition2013
Poor nutrition during pregnancy and lactation negatively affects neurodevelopment of the offspring: evidence from a translational primate model.
Article in The American journal of clinical nutrition, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 55 citations in OpenAlex.
- Association between fatty acid supplementation and prenatal stress in African Americans: a randomized controlled trial.Obstetrics and gynecology · 2014Trial
- Moderate maternal nutrient restriction alters type II alveolar epithelial cell density in the non-human primate fetal lung.Experimental physiology · 2026Article
- Animal models for understanding the mechanisms of malnutrition: a literature review.Frontiers in nutrition · 2025Review
- Diet quality during pregnancy, adolescent brain morphology, and cognitive performance in a population-based cohort.The American journal of clinical nutrition · 2024Article
- Forgotten Fundamentals: A Review of State Legislation on Nutrition for Incarcerated Pregnant and Postpartum People.Journal of correctional health care : the official journal of the National Commission on Correctional Health Care · 2024Review
- Effect of orally-administrated thymoquinone during pregnancy on litter size, pentylenetetrazol-induced seizure, and body weight in rat offspring.Iranian journal of basic medical sciences · 2021Article
- Effects of maternal stress and nutrient restriction during gestation on offspring neuroanatomy in humans.Neuroscience and biobehavioral reviews · 2020Review
- Exclusive Breastfeeding Predicts Higher Hearing-Language Development in Girls of Preschool Age.Nutrients · 2020Article
- Effect of maternal baboon (Papio sp.) dietary mismatch in pregnancy and lactation on post-natal offspring early life phenotype.Journal of medical primatology · 2019Article
- Ontogeny and programming of the fetal temporal cortical endocannabinoid system by moderate maternal nutrient reduction in baboons (Papio spp.).Physiological reports · 2019Article
- Reproductive cycling in adult baboons (Papio species) that were intrauterine growth restricted at birth implies normal fertility but increased psychosocial stress.Journal of medical primatology · 2018Article
- Prenatal influences on temperament development: The role of environmental epigenetics.Development and psychopathology · 2018Review
- Article
- Maternal activity, anxiety, and protectiveness during moderate nutrient restriction in captive baboons (Papio sp.).Journal of medical primatology · 2018Article
- 2D:4D digit ratio is not a biomarker of developmental programming in baboons (Papio hamadryas species).Journal of medical primatology · 2018Article
- Article
- Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype.Journal of medical primatology · 2017Article
- Cardiac remodelling in a baboon model of intrauterine growth restriction mimics accelerated ageing.The Journal of physiology · 2017Article
- Premature Brain Aging in Baboons Resulting from Moderate Fetal Undernutrition.Frontiers in aging neuroscience · 2017Article
- Prenatal Programming of Infant Neurobehaviour in a Healthy Population.Paediatric and perinatal epidemiology · 2016Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundStudies of the effects of prenatal nutrition on neurodevelopment in humans are complicated because poor nutrition occurs in the context of psychosocial stressors and other risk factors associated with poor developmental outcomes.
objectiveUnder controlled experimental conditions, we tested an effect of prenatal nutrition on neurodevelopmental outcomes in the nonhuman primate.
designJuvenile offspring of 19 female baboons, whose diets were either restricted [maternal nutrition restriction (MNR)] or who were fed ad libitum (control), were administered the progressive ratio task from the Cambridge Neuropsychological Test Automated Battery. Activity, persistence, attention, and emotional arousal were coded from videotapes. These established, reliable methods were consistent with those used to assess individual differences in the behaviors of school-age children.
resultsMNR offspring (3 female and 4 male offspring) had significantly fewer responses and received fewer reinforcements on the progressive ratio task than did control offspring (8 female and 4 male offspring). MNR offspring showed a more variable activity level and less emotional arousal than did control offspring. Female MNR offspring showed more variable and lower levels of persistence and attention than did female control offspring. Thus, under controlled experimental conditions, data support a main effect of prenatal nutrition on highly translatable neurodevelopmental outcomes.
conclusionsNutritional interventions during pregnancy have been successfully used to target neurodevelopmental problems, such as increasing folic acid intake during pregnancy to decrease the incidence of neural tube defects. Results from the current study can be used to support the testing of nutritional preventive interventions for the most-common childhood behavior problems.
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