Evidence map›Paper›PMID 23782994›Full record

ArticleJournal of human hypertension2014

Fetal sex and the circulating renin-angiotensin system during early gestation in women who later develop preeclampsia or gestational hypertension.

S D Sykes, K G Pringle, A Zhou, G A Dekker, C T Roberts, E R Lumbers, SCOPE consortium

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of human hypertension, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Plasma and serum prorenin concentrations in diabetes, hypertension, and renal disease.Hypertension research : official journal of the Japanese Society of Hypertension · 2022
    Article
  5. Review
  6. Review
  7. Circulating prorenin: its molecular forms and plasma concentrations.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

S D Sykes1] Mothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, Australia [2] Robinson Institute, University of Adelaide, Adelaide, SA, Australia.
K G PringleMothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, Australia.
A ZhouRobinson Institute, University of Adelaide, Adelaide, SA, Australia.
G A Dekker1] Robinson Institute, University of Adelaide, Adelaide, SA, Australia [2] Women's and Children's Division, Lyell McEwin Hospital, SA, Australia.
C T RobertsRobinson Institute, University of Adelaide, Adelaide, SA, Australia.
E R LumbersMothers and Babies Research Centre, Hunter Medical Research Institute, University of Newcastle, New Lambton Heights, NSW, Australia.
SCOPE consortium
Hunter Medical Research Institute · AUUniversity of Adelaide · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There are fetal sex-specific differences in the balance between angiotensin (Ang) II and Ang-(1-7) in the maternal circulation during pregnancy. To determine whether at 15 weeks' gestation plasma levels of Ang II and Ang-(1-7), as well as levels of prorenin and Ang-converting enzyme (ACE), predicted the development of gestational hypertension (GH) or preeclampsia (PreE) and were associated with estimates of fetal and maternal health, women who later developed GH (n=50) or PreE (n=50) were compared with body mass index-matched controls (n=100). Women who subsequently developed PreE or GH had increased Ang-(1-7) levels at 15 weeks' gestation compared with women with normal pregnancies. When separated by fetal sex, this difference was seen only in women carrying a female fetus. Prorenin and ACE concentrations were not useful biomarkers for the prediction of either PreE or GH at 15 weeks' gestation. Women with a male fetus who developed PreE and women who subsequently developed GH had increased blood pressures at 15 weeks' gestation compared with women with normal pregnancies, suggesting that these women were on an early trajectory for the development of hypertension. We propose that measurement of Ang-(1-7) during early gestation could be useful in predicting, those women who will go on to develop new-onset hypertension in pregnancy.

Indexed as

Blood PressureRenin-Angiotensin SystemAdultAngiotensin IAngiotensin IIBiomarkersCase-Control StudiesFemaleGestational AgeHumansHypertension, Pregnancy-InducedMalePeptide FragmentsPeptidyl-Dipeptidase APre-EclampsiaPregnancyACE protein, humanAngiotensin Iangiotensin I (1-7)Angiotensin IIBiomarkersPeptide FragmentsPeptidyl-Dipeptidase ARenin

Identifiers

PMID23782994
OpenAlexW2032006333

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.