ArticleEndocrinology2013
Leptin action in the ventromedial hypothalamic nucleus is sufficient, but not necessary, to normalize diabetic hyperglycemia.
Article in Endocrinology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 51 citations in OpenAlex.
- Hepatic translational rewiring in insulin deficiency identifies Reg3α as an insulin-independent glucoregulatory factor.Endocrinology · 2026Article
- Gut-brain axis in health and brain disease.Chinese medical journal · 2026Review
- An unexpected role for the brain in the pathogenesis of diabetic ketoacidosis.The Journal of clinical investigation · 2025Article
- Brain Defense of Glycemia in Health and Diabetes.Diabetes · 2024Review
- Dorsomedial Ventromedial Hypothalamic Nucleus Growth Hormone-Releasing Hormone Neuron Steroidogenic Factor-1 Gene Targets in Female Rat.ASN neuro · 2024Article
- Review
- Central Nervous System Control of Glucose Homeostasis: A Therapeutic Target for Type 2 Diabetes?Annual review of pharmacology and toxicology · 2022Review
- New Insights of SF1 Neurons in Hypothalamic Regulation of Obesity and Diabetes.International journal of molecular sciences · 2021Review
- Rap1 in the VMH regulates glucose homeostasis.JCI insight · 2021Article
- Central nervous system regulation of organismal energy and glucose homeostasis.Nature metabolism · 2021Review
- Cross-species analysis defines the conservation of anatomically segregated VMH neuron populations.eLife · 2021Article
- A neural basis for brain leptin action on reducing type 1 diabetic hyperglycemia.Nature communications · 2021Article
- Tissue-Specific Effects of Leptin on Glucose and Lipid Metabolism.Endocrine reviews · 2021Review
- Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.Diabetologia · 2021Review
- Leptin Receptors in RIP-CreFrontiers in endocrinology · 2020Article
- S100A9 extends lifespan in insulin deficiency.Nature communications · 2019Article
- Glucose-Lowering by Leptin in the Absence of Insulin Does Not Fully Rely on the Central Melanocortin System in Male Mice.Endocrinology · 2019Article
- In Uncontrolled Diabetes, Hyperglucagonemia and Ketosis Result From Deficient Leptin Action in the Parabrachial Nucleus.Endocrinology · 2018Article
- A role for leptin-regulated neurocircuitry in subordination stress.Physiology & behavior · 2017Review
- The glucoregulatory actions of leptin.Molecular metabolism · 2017Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
In rodent models of type 1 diabetes, leptin administration into brain ventricles normalizes blood glucose at doses that have no effect when given peripherally. The ventromedial nucleus of the hypothalamus (VMN) is a potential target for leptin's antidiabetic effects because leptin-sensitive neurons in this brain area are implicated in glucose homeostasis. To test this hypothesis, we injected leptin directly into the bilateral VMN of rats with streptozotocin-induced uncontrolled diabetes mellitus. This intervention completely normalized both hyperglycemia and the elevated rates of hepatic glucose production and plasma glucagon levels but had no effect on tissue glucose uptake in the skeletal muscle or brown adipose tissue as measured using tracer dilution techniques during a basal clamp. To determine whether VMN leptin signaling is required for leptin-mediated normalization of diabetic hyperglycemia, we studied mice in which the leptin receptor gene was deleted in VMN steroidogenic factor 1 neurons using cre-loxP technology. Our findings indicate leptin action within these neurons is not required for the correction of diabetic hyperglycemia by central leptin infusion. We conclude that leptin signaling in the VMN is sufficient to mediate leptin's antidiabetic action but may not be necessary for this effect. Leptin action within a distributed neuronal network may mediate its effects on glucose homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.