ArticleJournal of the American Heart Association2013
Carotid calcification in mice: a new model to study the effects of arterial stiffness on the brain.
Article in Journal of the American Heart Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Intracranial Arterial Calcification on Computed Tomography and Risk of Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis.Cerebrovascular diseases (Basel, Switzerland) · 2026Pooled it
- Systemic proportional pulse index is associated with incident probable dementia: aJournal of geriatric neurology · 2026Article
- Severity of Intracranial Arterial Calcification on Computed Tomography and Risk of Dementia in Patients With Stroke or Transient Ischemic Attack: A Population-Based Study.Journal of the American Heart Association · 2026Article
- The impact of age and sex on cerebral and large artery stiffness and the response to pulse pressure.American journal of physiology. Heart and circulatory physiology · 2025Article
- Estimated pulse wave velocity and incident cognitive impairment risk in stroke patients: a longitudinal cohort study.BMC cardiovascular disorders · 2025Article
- Neurovascular coupling over cortical brain areas and resting state network connectivity with and without rigidified carotid artery.Neurophotonics · 2025Article
- Impact of arterial stiffness on cerebrovascular function: a review of evidence from humans and preclincal models.American journal of physiology. Heart and circulatory physiology · 2024Review
- Effects of high-intensity interval training in a cold environment on arterial stiffness and cerebral hemodynamics in sedentary Chinese college female students post-COVID-19.Frontiers in neurology · 2024Article
- The Relationship of Cognitive Dysfunction with Inflammatory Markers and Carotid Intima Media Thickness in Schizophrenia.Journal of personalized medicine · 2023Article
- Neurovascular Coupling in Hypertension Is Impaired by IL-17A through Oxidative Stress.International journal of molecular sciences · 2023Article
- Pyridoxamine treatment ameliorates large artery stiffening and cerebral artery endothelial dysfunction in old mice.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Intracranial internal carotid artery calcification is not predictive of future cognitive decline.Alzheimer's research & therapy · 2022Observational
- The Impact of Aging on the Association Between Aortic Stiffness and Cerebral Pulsatility Index.Frontiers in cardiovascular medicine · 2022Article
- Effect of age stratification on the association between carotid intima-media thickness and cognitive impairment in Chinese hypertensive patients: new insight from the secondary analysis of the China Stroke Primary Prevention Trial (CSPPT).Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Exercise, Arterial Stiffness, and Cerebral Vascular Function: Potential Impact on Brain Health.Journal of the International Neuropsychological Society : JINS · 2021Review
- The Effect of High Fat Diet on Cerebrovascular Health and Pathology: A Species Comparative Review.Molecules (Basel, Switzerland) · 2021Review
- Large artery stiffness and brain health: insights from animal models.American journal of physiology. Heart and circulatory physiology · 2021Review
- Pathological Continuum From the Rise in Pulse Pressure to Impaired Neurovascular Coupling and Cognitive Decline.American journal of hypertension · 2020Review
- Arterial Stiffness Due to Carotid Calcification Disrupts Cerebral Blood Flow Regulation and Leads to Cognitive Deficits.Journal of the American Heart Association · 2019Article
- Common Carotid Artery Calcification Impacts on Cognitive Function in Older Patients.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundArterial stiffness has been identified as an important risk factor for cognitive decline. However, its effects on the brain's health are unknown, and there is no animal model available to study the precise impact of arterial stiffness on the brain. Therefore, the objective of the study was to develop and characterize a new model specific to arterial stiffness in order to study its effects on the brain. METHODS AND
resultsCalcium chloride (CaCl2) was applied to carotid arteries of mice, inducing an increase in collagen distribution and intima-media thickness, a fragmentation of elastin, a decrease in arterial compliance and distensibility, and an increase in cerebral blood flow pulsatility (n=3 to 11). Calcium deposits were only present at the site of CaCl2 application, and there was no increase in systemic blood pressure or change in vessel radius making this model specific for arterial stiffness. The effects of carotid stiffness were then assessed in the brain. Carotid calcification induced an increase in the production of cerebral superoxide anion and neurodegeneration, detected with Fluoro-Jade B staining, in the hippocampus (n=3 to 5), a key region for memory and cognition.
conclusionsA new model of arterial stiffness based on carotid calcification was developed and characterized. This new model meets all the characteristics of arterial stiffness, and its specificity allows the study of the effects of arterial stiffness on the brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.