ArticleBiology of reproduction2013
The Role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of two activity levels of the components of the extracellular signal-regulated kinase (ERK) pathway in the mouse epididymis.
Article in Biology of reproduction, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 18 citations in OpenAlex.
- Genome-Wide Association Study of Daughter Pregnancy Rate in Crossbred Dairy Cows.International journal of molecular sciences · 2025Article
- The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis†.Biology of reproduction · 2022Article
- Hippo kinases MST1 and MST2 control the differentiation of the epididymal initial segment via the MEK-ERK pathway.Cell death and differentiation · 2020Article
- A tale of two tracts: history, current advances, and future directions of research on sexual differentiation of reproductive tracts†.Biology of reproduction · 2019Review
- Epithelial dynamics in the epididymis: role in the maturation, protection, and storage of spermatozoa.Andrology · 2019Review
- Genomic and transcriptomic analyses reveal selection of genes for puberty in Bama Xiang pigs.Zoological research · 2018Article
- Initial Segment Differentiation Begins During a Critical Window and Is Dependent upon Lumicrine Factors and SRC Proto-Oncogene (SRC) in the Mouse.Biology of reproduction · 2016Article
- Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.Developmental biology · 2016Article
- Tyrosine kinase-mediated axial motility of basal cells revealed by intravital imaging.Nature communications · 2016Article
- The MAPK/ERK-Signaling Pathway Regulates the Expression and Distribution of Tight Junction Proteins in the Mouse Proximal Epididymis.Biology of reproduction · 2016Article
- Fibroblast Growth Factor Receptors (FGFRs) in Human Sperm: Expression, Functionality and Involvement in Motility Regulation.PloS one · 2015Article
- PTEN signaling through RAF1 proto-oncogene serine/threonine kinase (RAF1)/ERK in the epididymis is essential for male fertility.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- ROS1 signaling regulates epithelial differentiation in the epididymis.Endocrinology · 2014Article
- Regulation of epithelial function, differentiation, and remodeling in the epididymis.Asian journal of andrologyReview
- Understanding normal and abnormal development of the Wolffian/epididymal duct by using transgenic mice.Asian journal of andrologyReview
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3 authors at 1 institution in 1 country.
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Abstract
The components of the extracellular signal-regulated kinase (ERK) pathway are involved in the regulation of epididymal cellular processes. Interestingly, our previous studies showed that there are two different activity levels of the ERK pathway components in the epididymal epithelium: a basal level in most regions and a higher level in the differentiated initial segment (IS). In this study we analyzed the role of fibroblast growth factor receptor substrate 2 (FRS2) in the regulation of these two levels. Two mouse models were generated. In the first model, Frs2 was deleted from epithelial cells of most epididymal regions except for the IS from the embryonic period onward. Loss of Frs2 dampened the basal activity level of the ERK pathway components, which resulted in an increase in apoptosis along the epididymal duct. This was observed during the period when FRS2 expression level was highest in wild-type epididymides. In the second model, Frs2 was deleted from the proximal epididymal epithelium from Postnatal Day 17 onward. Most of the epididymides in this model exhibited normal morphology. Loss of Frs2 in these epididymides did not affect the high activity level of the ERK pathway components in the IS. However, a subgroup of epididymides in the second model showed increased apoptosis which resulted in an abnormally shaped proximal region or development of granulomas. Therefore, data from these two models showed that FRS2 played different roles in the regulation of two activity levels of the ERK pathway components in the epididymis.
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