Evidence map›Paper›PMID 23782686›Full record

ReviewLancet (London, England)2013

Retinopathy of prematurity.

Ann Hellström, Lois E H Smith, Olaf Dammann

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Lancet (London, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06044181 (Long Term Management of Peripheral Avascular Retina in Retinopathy of Prematurity Evaluated by Fundus Fluorescein Angiography.), which is not on this map. Cited by 506 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
506citing papers in PubMed, 7 pooled it
51.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06044181 naunknown statusnot on this mapstarted 2024, after this paper: background citation

Long Term Management of Peripheral Avascular Retina in Retinopathy of Prematurity Evaluated by Fundus Fluorescein Angiography.

TypeinterventionalSponsorAssiut UniversityRan2024 to 2025Enrolled32ConditionsRetinopathy of PrematurityArmsDiode laser photocoagulation.
3 · Its place in the literature

Who cites it

506 citing papers in PubMed, 7 syntheses or guidelines pooled it, 1,293 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article

446 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 3 countries.

Ann HellströmDepartment of Ophthalmology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Göteborg, Sweden.
Lois E H Smith
Olaf Dammann
Harvard University · USTufts Children's Hospital · USUniversity of Gothenburg · SE

Funding

Neonatal Biomarkers in Extremely Preterm Babies Predict Childhood Brain DisordersU01NS040069 · NINDS · CHILDREN'S HOSPITAL BOSTON · PI KUBAN, KARL · 2001 to 2014
$34.0M
SYNAPTIC MECHANISMS IN HIPPOCAMPAL EPILEPTOGENESISP30HD018655 · NICHD · CHILDREN'S HOSPITAL BOSTON · PI POMEROY, SCOTT LOREN · 1985 to 2015
$26.2M
Dietary control of angiogenesis in retinopathy modelsR01EY017017 · NEI · BOSTON CHILDREN'S HOSPITAL · PI Zhongjie Fu, Lois Smith · 2006 to 2026
$11.8M
Circulating Immune Biomarkers and Retinopathy of PrematurityR01EY021820 · NEI · TUFTS UNIVERSITY BOSTON · PI DAMMANN, OLAF · 2013 to 2016
$1.7M
Neuronal guidance molecules control revascularization in retinopathyR01EY022275 · NEI · BOSTON CHILDREN'S HOSPITAL · PI SMITH, LOIS · 2012 to 2014
$1.3M
NEI NIH HHS EY017017NEI NIH HHS EY021820NEI NIH HHS EY022275NEI NIH HHS R01 EY017017NEI NIH HHS R01 EY021820NEI NIH HHS R01 EY022275NICHD NIH HHS P01 HD18655NICHD NIH HHS P30 HD018655NINDS NIH HHS NS040069NINDS NIH HHS U01 NS040069
6 · The paper itself

Abstract

The immature retinas of preterm neonates are susceptible to insults that disrupt neurovascular growth, leading to retinopathy of prematurity. Suppression of growth factors due to hyperoxia and loss of the maternal-fetal interaction result in an arrest of retinal vascularisation (phase 1). Subsequently, the increasingly metabolically active, yet poorly vascularised, retina becomes hypoxic, stimulating growth factor-induced vasoproliferation (phase 2), which can cause retinal detachment. In very premature infants, controlled oxygen administration reduces but does not eliminate retinopathy of prematurity. Identification and control of factors that contribute to development of retinopathy of prematurity is essential to prevent progression to severe sight-threatening disease and to limit comorbidities with which the disease shares modifiable risk factors. Strategies to prevent retinopathy of prematurity will depend on optimisation of oxygen saturation, nutrition, and normalisation of concentrations of essential factors such as insulin-like growth factor 1 and ω-3 polyunsaturated fatty acids, as well as curbing of the effects of infection and inflammation to promote normal growth and limit suppression of neurovascular development.

Indexed as

CryotherapyDisease ProgressionEarly DiagnosisHumansHyperglycemiaHypoglycemic AgentsInfant, NewbornInsulin-Like Growth Factor IInsulinsLaser TherapyOxygenPrenatal DiagnosisRetinopathy of PrematurityRisk FactorsWeight GainHypoglycemic AgentsInsulin-Like Growth Factor IInsulinsOxygen

Identifiers

PMID23782686
PMCPMC4389630
OpenAlexW1998726711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.